About this Research Topic
Evidence has been presented to suggest a direct role of the microbiota on both the central and peripheral branches of the nervous system, suggesting bidirectional microbiota-gut-brain communication in health and disease. For example, the vagal afferents are able to sense gut dysbiosis and relay the message to the brain, while the efferent output to the gut aids in shaping of the microbiota-neuro-immune responses. Research into host-microbiota interaction yields evidence of direct microbiota influence on enteric nervous system function and production of neurotransmitters. Furthermore, microbiota metabolites are actively molding the central immune system responses, as the gut microbiota end-products contribute to maturation of CNS immune cells and the integrity of the blood brain barrier. Thus, the role of microbiota in psychological conditions like anxiety, and in cardiometabolic disorders like obesity, diabetes and hypertension is emerging.
The overall objective of this Research Topic is to present state-of-the-art research developments by leading scientists in the field, and provide innovative observations and future directions.
Keywords: gut microbiota, nervous system
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