The Interaction Between Redox and Programmed Cell Death in Malignancies

Oxidative stress is a condition that arises when there is an imbalance between reactive oxygen species (ROS) generation and antioxidant defences in cells. ROS, which is essential for various cellular processes, can become toxic in excess and result in oxidative damage to DNA, proteins, and lipids. This damage has been implicated in the pathogenesis of various diseases, including cancer. Additionally, programmed cell death (PCD) pathways, such as apoptosis, necroptosis, and ferroptosis, play important roles in tumorigenesis and their response to therapy. However, the intricate interplay between oxidative stress and these cell death pathways is yet to be completely understood. In recent years, there has been growing appreciation for the role of redox biology in regulating PCD in cancer cells. This interaction between redox and PCD offers a unique opportunity for the development of novel therapeutic approaches for malignancies. Therefore, a better understanding of the mechanisms underlying this interaction and the effects on cancer progression and response to therapy is urgently needed.

This Research Topic aims at a better understanding of the mechanisms involved in these processes. This study can be used to develop novel therapeutic approaches for the treatment of cancer. By targeting redox biology and regulating PCD pathways, it may be possible to selectively induce cell death in cancer cells while sparing normal cells. This could result in a more effective and less toxic treatment for cancer patients. Ultimately, the goal is to improve patient prognosis by developing targeted therapies that enhance the body's natural ability to regulate oxidative stress and PCD in cancer cells.

Authors are encouraged to submit Original Research articles, Reviews, or Perspective articles that address the interaction between redox and PCD in malignancies. We welcome submissions that apply diverse approaches, including molecular and cellular biology, biochemistry, and clinical studies.

We are especially interested in papers that address the following topics:
- Regulation of apoptosis, necroptosis, ferroptosis, and pyroptosis by redox signalling in malignancies
- Cross-talk between redox signalling and PCD pathways in the tumour microenvironment
- Molecular mechanisms underlying the modulation of redox signalling and PCD pathways in response to anticancer therapy
- The role of oxidative stress and PCD mechanisms in resistance to anticancer therapy
- Redox signalling and PCD in the initiation, progression, and metastasis of malignancies

Keywords: Ferroptosis, apoptosis, chemotherapy, natural compounds, reactive oxygen species

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