Perinatal Asphyxia and Resuscitation

Perinatal asphyxia is one of the leading causes of neonatal death or long-term neurological sequelae worldwide. Prompt identification of infants who need neonatal resuscitation and well-organized management in the delivery room can be life-saving. Approximately 3% of newborns require assistance to start breathing at birth, while 1% require intensive resuscitation intervention to restore cardiopulmonary function. For this reason, the Neonatal Resuscitation Program (NRP) was developed by the American Heart Association and the American Academy of Pediatrics in 1987, which recommends that any delivery should be attended by at least one well-trained person with primary responsibility for the newborn who can start resuscitation immediately.

This Research Topic aims to collect manuscripts investigating the pathophysiology from fetus to newborn transition, describing perinatal risk factors and hypoxic injuries associated with asphyxia, improving outcomes strategies with resuscitation, and more effective resuscitation training skills. We believe that exploring these aspects could improve our understanding of perinatal asphyxia and contribute to more effective resuscitation in this population.

We welcome submissions of Original Research articles, Reviews, and Meta-analysis which address the following sub-topics:

• Physiology from fetus to newborn transition;
• Pathophysiology of intrapartum fetal distress and/or resuscitation;
• Novel molecular and/or cellular mechanism of fetal hypoxic injury;
• Epidemiology of perinatal asphyxia and resuscitation;
• Challenges in neonatal resuscitation;
• Neonatal resuscitation training;
• Novel therapies for hypoxic ischemic encephalopathy.