About this Research Topic
Destruction of cartilage and bone tissue in the craniomaxillofacial region can lead to temporomandibular joint disease, occlusal disorders, and tooth loss. These conditions greatly impact essential physiological functions such as mouth opening, chewing, swallowing, and pronunciation, significantly reducing the patient’s quality of life. Such challenging clinical problem necessitates urgent resolution and causes considerable distress to affected individuals. Researchers are earnestly exploring various approaches including integrative pharmacological strategies, stem cell therapies, and tissue engineering, hoping to stimulate and facilitate cartilage and bone regeneration. Despite substantial progress, identifying the most effective and sustainable methods for promoting cartilage and bone repair remains a complex challenge within the fields of regenerative medicine.
The regeneration of cartilage is inherently curtailed by inadequate vascularization and limited availability of nutrients and immune cells. This hampers its self-repair capabilities in cases of damage or degradation, thus posing a significant challenge for individuals suffering from degenerative conditions such as cartilage injury or osteoarthritis. Despite bone tissue exhibiting robust metabolic activity, present approaches for addressing bone defects, including autologous and allogeneic bone transplantation, still exhibit certain deficiencies. The field of bone regeneration confronts several obstacles such as the limited effectiveness of existing biomaterials, difficulty in achieving seamless integration with host tissue, inadequate vascularization, and slow healing processes. Additionally, personalized treatment approaches and handling complex bone defects remain concerning areas. In an attempt to overcome these challenges, researchers are investigating strategies involving the use of growth factors, stem cells, and bioactive molecules delivered through scaffolds or carriers to enhance tissue regeneration. Tissue engineering and 3D printing methodologies are being deployed to devise personalized implants and structures that facilitate the repair of cartilage and bone. This research topic aims to present the most recent studies in the field of cartilage and bone tissue regeneration, therefore providing a reference point for future clinical applications.
In this Research Topic, we would like to include articles in the form of Original Research, Review/Opinion/Perspective, and Clinical Trial/Case Report. We invite contributions that relate to, but are not limited to, the following topics:
• Pharmacological interventions facilitating the regeneration of cartilage or bone tissue.
• Genetic manipulation techniques promoting the regeneration of cartilage or bone tissue.
• Use of stem cells as a therapeutic tactic to stimulate the regeneration of cartilage or bone tissue.
• The application of tissue engineering techniques involving cells, scaffold materials, and other components to promote the regeneration of cartilage or bone tissue.
The regeneration of cartilage is inherently curtailed by inadequate vascularization and limited availability of nutrients and immune cells. This hampers its self-repair capabilities in cases of damage or degradation, thus posing a significant challenge for individuals suffering from degenerative conditions such as cartilage injury or osteoarthritis. Despite bone tissue exhibiting robust metabolic activity, present approaches for addressing bone defects, including autologous and allogeneic bone transplantation, still exhibit certain deficiencies. The field of bone regeneration confronts several obstacles such as the limited effectiveness of existing biomaterials, difficulty in achieving seamless integration with host tissue, inadequate vascularization, and slow healing processes. Additionally, personalized treatment approaches and handling complex bone defects remain concerning areas. In an attempt to overcome these challenges, researchers are investigating strategies involving the use of growth factors, stem cells, and bioactive molecules delivered through scaffolds or carriers to enhance tissue regeneration. Tissue engineering and 3D printing methodologies are being deployed to devise personalized implants and structures that facilitate the repair of cartilage and bone. This research topic aims to present the most recent studies in the field of cartilage and bone tissue regeneration, therefore providing a reference point for future clinical applications.
In this Research Topic, we would like to include articles in the form of Original Research, Review/Opinion/Perspective, and Clinical Trial/Case Report. We invite contributions that relate to, but are not limited to, the following topics:
• Pharmacological interventions facilitating the regeneration of cartilage or bone tissue.
• Genetic manipulation techniques promoting the regeneration of cartilage or bone tissue.
• Use of stem cells as a therapeutic tactic to stimulate the regeneration of cartilage or bone tissue.
• The application of tissue engineering techniques involving cells, scaffold materials, and other components to promote the regeneration of cartilage or bone tissue.
Keywords: Cartilage, bone tissue, regenerative therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
