About this Research Topic
Currently, there are no effective disease-modifying treatments for most neurodegenerative disorders. Emerging evidence suggests treatment and prevention are equally important in the clinical management of neurodegenerative diseases. Previous studies have confirmed the potential neuroprotective effects of physical exercise in preventing and treating a wide variety of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. A scientific and reasonable exercise training regimen is essential in exerting neuroprotective effects and alleviating pathological changes. However, the most effective parameters that affect the therapeutic efficiency of physical exercise, including frequency, intensity, time, initiation time, and exercise types, in various neurodegenerative diseases remain unclear. Additionally, although studies have investigated the underlying mechanisms responsible for the neuroprotective effects of physical effects, many detailed underlying molecular mechanisms remain elusive.
Understanding the effects of physical exercise with the different treatment regimens on various neurodegenerative diseases and deciphering a more in-depth understanding of the underlying molecular mechanisms will be of high research and clinical value in the clinical management of neurodegenerative diseases. This research topic aims to collect studies evaluating the effects of different types of physical exercise with various parameters on neurodegenerative diseases, including but not limited to Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Original papers uncovering the novel mechanisms underlying physical exercise’s neuroprotection and reviews discussing the recent advances and challenges in this field are expected.
Potential areas of interest may include, but are not limited to:
• The preparative or conditioning regimen of exercise on neurodegenerative diseases;
• Effects of exercise treatment for neurodegenerative diseases;
• Mechanism underlying mitochondrial changes following exercise in neurodegenerative diseases;
• Neurotrophic and neuroprotective peptides in the central nervous system following exercise in neurodegenerative diseases;
• Changes of glial cells following exercise in neurodegenerative diseases;
• Cellular senescence following exercise in neurodegenerative diseases;
• Exercise and blood-brain barrier protection in neurodegenerative diseases.
Understanding the effects of physical exercise with the different treatment regimens on various neurodegenerative diseases and deciphering a more in-depth understanding of the underlying molecular mechanisms will be of high research and clinical value in the clinical management of neurodegenerative diseases. This research topic aims to collect studies evaluating the effects of different types of physical exercise with various parameters on neurodegenerative diseases, including but not limited to Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Original papers uncovering the novel mechanisms underlying physical exercise’s neuroprotection and reviews discussing the recent advances and challenges in this field are expected.
Potential areas of interest may include, but are not limited to:
• The preparative or conditioning regimen of exercise on neurodegenerative diseases;
• Effects of exercise treatment for neurodegenerative diseases;
• Mechanism underlying mitochondrial changes following exercise in neurodegenerative diseases;
• Neurotrophic and neuroprotective peptides in the central nervous system following exercise in neurodegenerative diseases;
• Changes of glial cells following exercise in neurodegenerative diseases;
• Cellular senescence following exercise in neurodegenerative diseases;
• Exercise and blood-brain barrier protection in neurodegenerative diseases.
Keywords: Neurodegenerative Diseases, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, Excercise
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