Advances and Applications of Predictive Toxicology in Knowledge Discovery, Risk Assessment, and Drug Development

2,636
Total Downloads
10k
Total Views and Downloads

Articles

ORIGINAL RESEARCH

Published on 11 Nov 2024

Delayed immune-related adverse events profile associated with immune checkpoint inhibitors: a real-world analysis

Yana Yang
Linman Li
Jing Tian
Linwen Ma
Yaoxin Wu
Qian Luo
Yan Luo

doi 10.3389/fphar.2024.1453429

422 views

ORIGINAL RESEARCH

Published on 29 Oct 2024

Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment

Christopher J. Morris
Michael G. Rolf
Linda Starnes
Inmaculada C. Villar
Amy Pointon
Holly Kimko
Giovanni Y. Di Veroli

Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment

doi 10.3389/fphar.2024.1402462

384 views

ORIGINAL RESEARCH

Published on 28 Aug 2024

A real-world pharmacovigilance study of KRAS G12C mutation inhibitors based on the food and drug administration adverse event reporting system

Lisha Wu
Maosheng Xu
Xueqin Li
Dilinuer Aierken
Jinxiu Yu
Tao Qin

A real-world pharmacovigilance study of KRAS G12C mutation inhibitors based on the food and drug administration adverse event reporting system

doi 10.3389/fphar.2024.1418469

942 views

ORIGINAL RESEARCH

Published on 09 Aug 2024

Assessing the immunogenicity risk of salmon calcitonin peptide impurities using in silico and in vitro methods

Brian J. Roberts
Aimee E. Mattei
Kristina E. Howard
James L. Weaver
Hao Liu
Sandra Lelias
William D. Martin
Daniela Verthelyi
Eric Pang
1 more
Anne S. De Groot

Assessing the immunogenicity risk of salmon calcitonin peptide impurities using in silico and in vitro methods

doi 10.3389/fphar.2024.1363139

2,057 views

ORIGINAL RESEARCH

Published on 20 Jun 2024

Toxicological safety assessment of a water extract of Lithocarpus litseifolius by a 90-day repeated oral toxicity study in rats

Jinfeng Ma
Yujia Wei
Jingfeng Sun
Fang Tan
Penghe Liu
Guangqiu Qin

Toxicological safety assessment of a water extract of Lithocarpus litseifolius by a 90-day repeated oral toxicity study in rats

doi 10.3389/fphar.2024.1385550

400 views

ORIGINAL RESEARCH

Published on 19 Jun 2024

Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells

Minmin Qu
Jia Chen
Bin Xu
Qinyun Shi
Shujing Zhao
Zhaoxia Wang
Zhi Li
Bo Ma
Hua Xu
1 more
Jianwei Xie

Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells

doi 10.3389/fphar.2024.1356753

730 views

ORIGINAL RESEARCH

Published on 21 Feb 2024

Prediction of risk factors for linezolid-induced thrombocytopenia based on neural network model

Xian Zhao
Qin Peng
Dongmei Hu
Weiwei Li
Qing Ji
Qianqian Dong
Luguang Huang
Miyang Piao
Yi Ding
Jingwen Wang

Prediction of risk factors for linezolid-induced thrombocytopenia based on neural network model

doi 10.3389/fphar.2024.1292828

942 views
1 citation

ORIGINAL RESEARCH

Published on 21 Feb 2024

Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model

Shu-Yan Gao
Jing-Cheng Zhao
Qing Xia
Chen Sun
Maimaiti Aili
Ainiwaer Talifu
Shi-Xia Huo
Yun Zhang
Zhi-Jian Li

Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model

doi 10.3389/fphar.2024.1308655

1,117 views

Share on

Frontiers in Pharmacology

Frontiers in Pharmacology

Predictive Toxicology

Impact

10kTopic views
6,361Article views
2,636Article downloads