About this Research Topic
Acute kidney injury (AKI) is a prevalent condition characterized by significant morbidity and mortality, often closely linked with the emergence and progression of chronic kidney disease (CKD). Prolonged renal recovery can result from tubular cell dysfunction/damage, interstitial inflammation, and peritubular microvasculopathy. The realm of posttranslational protein modifications is widely implicated in various pathological conditions, encompassing cancer, inflammation, and oxidative stress responses. However, the intricate role and mechanisms governed by posttranslational protein modifications in kidney injury remain elusive.
We invite both experimental and theoretical research contributions focusing on renal interstitial fibrosis and posttranslational protein modifications. Particularly, we seek insights into the roles and mechanisms enacted by diverse cell types during Kidney Injury.
This Research Topic delves into "The Role and Mechanism of Interstitial Microenvironment Alterations in Kidney Injury." We aspire to unravel the dynamics of interstitial microenvironment changes in both acute and chronic kidney injuries, deciphering their intricate mechanisms. Our endeavour holds promise in identifying potential therapeutic targets and intervention strategies to address kidney injuries. Topics of interest include but are not limited to:
● The role and mechanism of interstitial fibrosis in kidney injury
● The role and mechanism of posttranslational modification of proteins in kidney injury
● The role and mechanism of endothelial dysfunction in kidney injury
● The role and mechanism of pericyte activation in kidney injury
● The role and mechanism of mesenchymal stem cell (MSC)-derived exosomes in kidney injury
● The role and mechanism of epithelial-mesenchymal transition in kidney injury
● The role and mechanism of macrophage recruitment, activation, polarization, and phenotype switch in kidney injury
We invite both experimental and theoretical research contributions focusing on renal interstitial fibrosis and posttranslational protein modifications. Particularly, we seek insights into the roles and mechanisms enacted by diverse cell types during Kidney Injury.
This Research Topic delves into "The Role and Mechanism of Interstitial Microenvironment Alterations in Kidney Injury." We aspire to unravel the dynamics of interstitial microenvironment changes in both acute and chronic kidney injuries, deciphering their intricate mechanisms. Our endeavour holds promise in identifying potential therapeutic targets and intervention strategies to address kidney injuries. Topics of interest include but are not limited to:
● The role and mechanism of interstitial fibrosis in kidney injury
● The role and mechanism of posttranslational modification of proteins in kidney injury
● The role and mechanism of endothelial dysfunction in kidney injury
● The role and mechanism of pericyte activation in kidney injury
● The role and mechanism of mesenchymal stem cell (MSC)-derived exosomes in kidney injury
● The role and mechanism of epithelial-mesenchymal transition in kidney injury
● The role and mechanism of macrophage recruitment, activation, polarization, and phenotype switch in kidney injury
Keywords: Interstitial microenvironment, kidney injury, inflammation, immunity, fibrosis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
