About this Research Topic
Stem cell therapy is a promising approach for the treatment of various diseases, including cardiovascular diseases. Stem cells possess embryonic cell-like characteristics and can self-renew, proliferate, differentiate into target cell types, and produce a plethora of cytokines and growth factors necessary to induce the regeneration of lost or diseased tissues and organs and modulate immune responses. Despite significant advancements, the field faces several challenges, such as optimizing cell isolation, expansion, delivery, survival, and engraftment. Recent studies have shown promising results using bone-marrow-derived mesenchymal stem cells (BM-MSCs) and induced pluripotent stem cells (iPSCs) for cardiovascular regeneration. However, issues like off-target effects, tumor formation, and mutagenesis remain unresolved. Addressing these challenges is crucial for translating laboratory findings into clinical applications and ensuring the safety and efficacy of stem cell therapies.
This research topic aims to thoroughly examine the types of stem cells utilized for the regeneration of cardiovascular tissues and organs damaged or abnormal due to congenital defects or disease conditions. Specifically, the focus will be on investigating the roles of iPSCs and MSCs in cardiac and vascular regeneration. The research will address major challenges these stem cell types face in clinical applications, including cell isolation, expansion, delivery, survival, engraftment, off-target effects, tumor formation, and mutagenesis. Additionally, the study will explore concerns related to arrhythmias in cardiac tissue regeneration and the molecular mechanisms to mitigate these conditions.
To gather further insights into the scope of stem cell therapy in cardiovascular regenerative medicine, we welcome articles addressing, but not limited to, the following themes:
- Mechanisms of stem cell differentiation into cardiovascular cell types.
- Optimization of stem cell isolation, expansion, and delivery methods
Strategies to enhance stem cell survival and engraftment in cardiovascular tissues.
- Addressing off-target effects and tumor formation in stem cell therapies.
- Molecular mechanisms underlying arrhythmias in stem cell-derived cardiomyocytes.
- Role of stem/progenitor cells in vascular regeneration and reversal of vascular damage.
- Collaborative efforts between academia and industry in advancing stem cell research.
- Clinical trials and case studies on stem cell therapies for cardiovascular diseases.
This research topic aims to thoroughly examine the types of stem cells utilized for the regeneration of cardiovascular tissues and organs damaged or abnormal due to congenital defects or disease conditions. Specifically, the focus will be on investigating the roles of iPSCs and MSCs in cardiac and vascular regeneration. The research will address major challenges these stem cell types face in clinical applications, including cell isolation, expansion, delivery, survival, engraftment, off-target effects, tumor formation, and mutagenesis. Additionally, the study will explore concerns related to arrhythmias in cardiac tissue regeneration and the molecular mechanisms to mitigate these conditions.
To gather further insights into the scope of stem cell therapy in cardiovascular regenerative medicine, we welcome articles addressing, but not limited to, the following themes:
- Mechanisms of stem cell differentiation into cardiovascular cell types.
- Optimization of stem cell isolation, expansion, and delivery methods
Strategies to enhance stem cell survival and engraftment in cardiovascular tissues.
- Addressing off-target effects and tumor formation in stem cell therapies.
- Molecular mechanisms underlying arrhythmias in stem cell-derived cardiomyocytes.
- Role of stem/progenitor cells in vascular regeneration and reversal of vascular damage.
- Collaborative efforts between academia and industry in advancing stem cell research.
- Clinical trials and case studies on stem cell therapies for cardiovascular diseases.
Keywords: cardiovascular disease, stem cell therapy, BM-MSC, iPSCs, cardiovascular medicine, regenerative medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
