Viral infection pathogenesis and pathology in nervous system

Virus infection in the nervous system is serious and burdensome problem with severe morbidity and mortality. The severity of virus infection in nervous system results in encephalitis, myelitis and immune modulation leading to psychiatric symptoms. To date, there are several neurotropic viruses have been reported including Japanese encephalitis virus, herpes simplex virus, Rabies virus, Coxsackievirus, Poliovirus, West Nile virus, Varicella-zoster virus, St. Louis encephalitic virus, Zika virus, tick-borne encephalitis virus, mumps virus, measles virus and, Borna disease virus (BoDV-1). Recently, there is evidence that non-neurotropic virus such as Dengue virus, SARS-CoV-2, H3N2 Influenza A Virus, Nipah virus, human immunodeficiency virus (HIV) can cause neuropathological symptoms.



The goal is to explore the underling mechanisms on neuropathology and pathogenesis during neurotropic and non-neurotropic viral infection.



The scope of this research topic is to explore in detail about

1. Molecular mechanism (gene expression, gene regulation and signaling) on neuropathology and neuropathogenesis of neurotropic as well as non-neurotropic virus.

2. Immunopathology and immune evasion strategies mediated by neurotropic/non-neurotropic virus in neuro-pathology and -pathogenesis.

3. Mechanisms utilized by viruses in crossing blood-brain barrier and blood-cerebrospinal fluid barrier.

4. Experimental evidence on neuropathogenesis and pathology in neurotropic and non-neurotropic virus infection.

5. The impact of non-coding RNAs (miRNA, lncRNA, etc) in pathogenesis and pathology upon neurotropic/non-neurotropic virus infection in nervous system.



Review, Mini-Review, Original research, General Commentary, Perspective articles on all the sub-themes mentioned above and related areas are welcome as contributions to this Research Topic. Novel case reports are also welcomed.