About this Research Topic
Bacteria and virus-induced Infectious diseases are becoming a major healthcare issue worldwide. Recently, the gut microbiota has been shown to play a significant role in regulating infectious disease outcomes by interacting with the host immune system, especially the innate immune system. As the first line of defense against pathogen invasion, innate immunity plays an important role in responses to pathogens. Gut microbiota primes host innate immunity and plays a critical role in the development, training, and function of the immune system throughout life, and dysbiosis of gut microbiota is also associated with alterations of the immune system. Metabolites of gut microbiota have been reported to involve innate immune pathways and regulate the immune response. Furthermore, gut microbiota can affect the function of innate immune cells including macrophages, monocytes, neutrophils, dendritic cells, and so on, thereby regulating the innate immune system against pathogenic microorganisms. The effects of the gut microbiota on the innate immune system in the development of infectious diseases and the related mechanism deserve further attention, and the microbiota components driving the effects need to be better characterized.
In this Research Topic, we encourage research focusing on the relationship between gut microbiota and innate immune response to pathogens, aiming to explore the roles of gut microbiota and the metabolites in infectious diseases in terms of innate immune and provide the related prevention, diagnosis and treatment strategies. Both Original Research and Review articles are welcome here, including, but not limited to, the following research contents:
1. The effect of gut microbiota and the metabolites on host innate immune response to infection
2. Mechanisms of gut microbiota affecting host innate immune in the development of infectious diseases
3. Prevention and diagnosis of infectious diseases based on the interplay between gut microbiota and innate immune
4. Probiotics, synbiotics, herbal medicines and other therapies for infectious diseases based on the interplay between gut microbiota and innate immune
In this Research Topic, we encourage research focusing on the relationship between gut microbiota and innate immune response to pathogens, aiming to explore the roles of gut microbiota and the metabolites in infectious diseases in terms of innate immune and provide the related prevention, diagnosis and treatment strategies. Both Original Research and Review articles are welcome here, including, but not limited to, the following research contents:
1. The effect of gut microbiota and the metabolites on host innate immune response to infection
2. Mechanisms of gut microbiota affecting host innate immune in the development of infectious diseases
3. Prevention and diagnosis of infectious diseases based on the interplay between gut microbiota and innate immune
4. Probiotics, synbiotics, herbal medicines and other therapies for infectious diseases based on the interplay between gut microbiota and innate immune
Keywords: infectious diseases, innate immune, signaling pathway, gut microbiota
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
