About this Research Topic
Epigenetic silencing of tumor suppressor genes (TSGs) is a common and crucial event in cancer development and progression. It involves aberrant DNA methylation and histone modifications that result in transcriptional repression of genes which regulate key cellular functions, such as cell cycle, apoptosis, differentiation, and DNA repair. Epigenetic silencing can occur at different stages of tumorigenesis, from pre-invasive lesions to metastatic tumors, and can affect multiple pathways that are involved in oncogenesis. Epigenetic silencing can also confer resistance to conventional therapies and influence the prognosis and survival of cancer patients. Therefore, understanding the molecular mechanisms and functional consequences of epigenetic silencing of TSGs in different types of cancer, and exploring the potential of reversing these epigenetic silencing events, are essential for developing novel diagnostic and therapeutic strategies.
The aim of the current Research Topic is to cover promising, recent, and novel research trends in the role and mechanisms of epigenetic silencing of TSG in cancer development. Areas to be covered in this Research Topic may include, but are not limited to:
• The molecular mechanisms by which epigenetic silencing of TSGs is mediated by DNA methyltransferases (DNMTs), histone deacetylases (HDACs), histone methyltransferases (HMTs), chromatin remodeling complexes, and non-coding RNAs
• The functional consequences of epigenetic silencing of TSGs on cancer cell proliferation, invasion, metastasis, and drug resistance
• The therapeutic potential of epigenetic editing tools or pharmacological approaches in reversing epigenetic silencing of TSGs
• How epigenetic silencing of genes in aging might contribute to cancer development
The aim of the current Research Topic is to cover promising, recent, and novel research trends in the role and mechanisms of epigenetic silencing of TSG in cancer development. Areas to be covered in this Research Topic may include, but are not limited to:
• The molecular mechanisms by which epigenetic silencing of TSGs is mediated by DNA methyltransferases (DNMTs), histone deacetylases (HDACs), histone methyltransferases (HMTs), chromatin remodeling complexes, and non-coding RNAs
• The functional consequences of epigenetic silencing of TSGs on cancer cell proliferation, invasion, metastasis, and drug resistance
• The therapeutic potential of epigenetic editing tools or pharmacological approaches in reversing epigenetic silencing of TSGs
• How epigenetic silencing of genes in aging might contribute to cancer development
Keywords: Cancer Epigenetics, Epigenetic Dysregulations, EpiDrivers, Tumorigenesis, Epigenetic Editing
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
