About this Research Topic
Parkinson disease (PD) is a complex, chronic, highly disabling condition caused by the degeneration of the dopaminergic nigrostriatal neurons of the basal ganglia, for which there is not yet a cure. Both motor and non-motor symptoms can significantly affect daily functioning. Aerobic or anaerobic exercise and/or adoption of a more physically active lifestyle are often encouraged beginning at diagnosis of PD, as an empowering non-pharmacological approach to self-management under the direct control of individuals living with PD. Emerging evidence suggests aerobic exercise may influence mood, cognition and/or motor control and possibly disease progression in human PD through adaptive neuroplasticity in multiple brain regions including exercise-induced structural changes in the sensorimotor cortex and the striatum.
The goal of this research topic is to feature studies with a focus on the exercise-induced attenuation of motor and/or non-motor progression of PD, with focus on effects of exercise on neuroplasticity in human PD brain, to bring such insights into the clinical context of rehabilitation for people living with PD.
We welcome manuscripts of studies reporting effect of physical exercise on clinical outcomes with neuroplasticity in human PD and/or that explore the neurobiological mechanisms of exercise-induced neuroplasticity in PD, such as changes in brain structure, connectivity, and function, including but not limited to: changes in endogenous corticostriatal concentration of neurotrophins (such as brain-derived neurotrophic factor and others), cortical activation, corticostriatal network connectivity including modification of dysfunctional striatal brain circuitry, reorganization of corticostriatal function, and changes seen with exercise in brain inflammation, dopaminergic signaling, dopamine transporter level, or dopamine receptor density or function. We welcome submissions of well powered, hypothesis driven prospective, retrospective, observational, laboratory or community-based studies, case studies, case-series, or systematic meta-analytic reviews in human PD. We welcome manuscripts on effects of exercise in human PD imaging outcomes (e.g., magnetic resonance imaging, positron emission tomography and others) in relation to PD-related outcomes, including but not limited to cognitive function, mood, gait, balance, and quality of life and subsequent therapeutic implications.
The goal of this research topic is to feature studies with a focus on the exercise-induced attenuation of motor and/or non-motor progression of PD, with focus on effects of exercise on neuroplasticity in human PD brain, to bring such insights into the clinical context of rehabilitation for people living with PD.
We welcome manuscripts of studies reporting effect of physical exercise on clinical outcomes with neuroplasticity in human PD and/or that explore the neurobiological mechanisms of exercise-induced neuroplasticity in PD, such as changes in brain structure, connectivity, and function, including but not limited to: changes in endogenous corticostriatal concentration of neurotrophins (such as brain-derived neurotrophic factor and others), cortical activation, corticostriatal network connectivity including modification of dysfunctional striatal brain circuitry, reorganization of corticostriatal function, and changes seen with exercise in brain inflammation, dopaminergic signaling, dopamine transporter level, or dopamine receptor density or function. We welcome submissions of well powered, hypothesis driven prospective, retrospective, observational, laboratory or community-based studies, case studies, case-series, or systematic meta-analytic reviews in human PD. We welcome manuscripts on effects of exercise in human PD imaging outcomes (e.g., magnetic resonance imaging, positron emission tomography and others) in relation to PD-related outcomes, including but not limited to cognitive function, mood, gait, balance, and quality of life and subsequent therapeutic implications.
Keywords: Parkinson Disease, Neuronal plasticity, rehabilitation, exercise, physical therapy, clinical trials
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