About this Research Topic
The immune system is an incredible regulatory system that strikes an ever-shifting balance between immune and non-immune cells. Immune modulation methods have broad biomedical applications, including but not limited to cancer immunotherapies, regenerative medicine, treatment of autoimmune disorders, and the discovery of novel vaccines. To address this issue, researchers are developing biomaterials that can precisely regulate the immune cell functions of the body. Attempts to restore normal biological function by regenerating damaged or diseased cells, tissues, or organs; constitute the growing interdisciplinary subject of regenerative medicine. Despite advanced progress in cell-based therapies, current treatment methods still have some drawbacks, such as the time and effort required for in vitro culture, the inefficiency of scaffolds and biomaterial in delivering cells, and the poor incorporation and grafting efficiencies. Because of this, in vivo editing has recently become a cutting-edge tool for medical care. In vivo reprogramming is the process of changing one cell type into another within a living body. It has been successfully used in research, providing new therapeutic choices for several organs or tissue disorders. The dynamic orchestration of cellular networks of damaged tissues via immune cells plays a vital role in tissue repair and regeneration. Immune cells like neutrophils, macrophages, and lymphocytes reprogram damaged tissues via augmenting several factors like anti-inflammation, angiogenesis, and phagocytosis of pathological debris, which supports cellular orchestration and the repair process. However, the incompetence of these cells due to signaling complexities during disorders or injuries has limited their usefulness as a translational and potent source of cell therapy.
Self-adaptive responses can set off a cascade of stimuli necessary for regulating the foreign body response and repair processes and can involve numerous layered interactions at the cellular, protein, and nucleic acid levels. However, creating safe and effective therapies and reliably manipulating immune responses are hampered by the complexity of the cellular and molecular signals that regulate the immune system. To overcome this obstacle, scientists are working to create biomaterials that can precisely regulate immune cell differentiation in vitro and regulate when, where, and how immune cells are activated in vivo. In this special issue, we look back at the recent developments in the field of biomaterials for immunomodulation, with a special emphasis on the design of biomaterials to provide controlled in vivo reprogramming, and the use of scaffolds to organize immune cells and mimic in vivo condition. These ongoing endeavors demonstrate the wide range of biomaterials, natural products, and polymers that can be utilized in in-vivo reprogramming engineering for translational application.
- Different types of Biomaterials for surgical implantation.
- Application of In-situ bioprinting and its immunological aspect.
- Natural product derived polymeric biomaterial and its translational ability.
- Transplant Immunology and foreign body response.
- 3D printing and personalized medicine for immunogenic response.
- Point of care treatment and their immune surveillance.
- Immunological surveillance of surface engineered biomaterial in drug delivery.
- In vivo reprogramming of different surgical implant.
- Decellularized extracellular matrix for surgical implantation and their immunotolerance.
- Polarized macrophage and their translational ability.
Self-adaptive responses can set off a cascade of stimuli necessary for regulating the foreign body response and repair processes and can involve numerous layered interactions at the cellular, protein, and nucleic acid levels. However, creating safe and effective therapies and reliably manipulating immune responses are hampered by the complexity of the cellular and molecular signals that regulate the immune system. To overcome this obstacle, scientists are working to create biomaterials that can precisely regulate immune cell differentiation in vitro and regulate when, where, and how immune cells are activated in vivo. In this special issue, we look back at the recent developments in the field of biomaterials for immunomodulation, with a special emphasis on the design of biomaterials to provide controlled in vivo reprogramming, and the use of scaffolds to organize immune cells and mimic in vivo condition. These ongoing endeavors demonstrate the wide range of biomaterials, natural products, and polymers that can be utilized in in-vivo reprogramming engineering for translational application.
- Different types of Biomaterials for surgical implantation.
- Application of In-situ bioprinting and its immunological aspect.
- Natural product derived polymeric biomaterial and its translational ability.
- Transplant Immunology and foreign body response.
- 3D printing and personalized medicine for immunogenic response.
- Point of care treatment and their immune surveillance.
- Immunological surveillance of surface engineered biomaterial in drug delivery.
- In vivo reprogramming of different surgical implant.
- Decellularized extracellular matrix for surgical implantation and their immunotolerance.
- Polarized macrophage and their translational ability.
Keywords: Biomaterial, 3D Biopirnting, Immune response, In vivo reprogramming, Macrophage
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
