About this Research Topic
The liver, as an important organ, owns multiple biological functions such as detoxification, metabolism, biliary secretion, immunity, and coagulation, which play an important role in maintaining the homeostasis of the body. The role properties of liver detoxification and metabolism determine its susceptibility to various types of damage factors. Therefore, as the outcome of experiencing damage factors, liver injury is frequent in clinical practice. Liver injury is divided into two parts: acute injury and chronic injury. The common damage factors include hepatic ischemia-reperfusion injury, drug-induced liver damage, viral hepatitis, alcoholic liver disease, toxic-induced liver damage, etc. Severe liver injury sometimes results in a loss of hepatic function which can be life-threatening. Meanwhile, prolonged liver injury may contribute to the occurrence of hepatocellular carcinoma (HCC). Thus, the potential mechanism of liver injury and HCC requires further investigation.
At present, there are relatively few treatments for liver injury, and the metabolic disorders caused by liver damage are more difficult to deal with. In current clinical practice, hepatoprotective drugs are commonly used to protect the damaged liver. The artificial liver is often used as a replacement treatment for liver failure, but its effectiveness is limited. The aim of this research topic is to reveal the mechanism of liver injury and the molecular target of alleviating liver injury. It is necessary to alleviate liver injury and maintain basic liver function, and avoid liver cancer caused by long-term liver damage. So far, there have been several treatments, such as traditional Chinese medicine, mesenchymal stem cells, small molecule inhibitors, and so on. More therapies need to be discovered to improve the prognosis of patients with liver injury or HCC.
In this Research Topic, we invite investigators to submit Original Research articles as well as Review articles to present new data, review cutting-edge techniques, and develop new ideas to promote these advancements. We are interested in articles that describe basic and clinical research on liver injury and HCC.
Potential subtopics include, but are not limited to the following:
1. Recent advances in acute/chronic liver injury and HCC;
2. New mechanism of acute/chronic liver injury and HCC;
3. New drug/treatment for acute/chronic liver injury and HCC;
4. New advances in metabolic reprogramming, immune infiltration, inflammatory response in acute/chronic liver injury and HCC;
5. New advances in molecular signaling crosstalk between parenchymal and nonparenchymal cells in acute/chronic liver injury and HCC;
6. Clinical application of therapeutic strategy in treating liver injury and HCC.
At present, there are relatively few treatments for liver injury, and the metabolic disorders caused by liver damage are more difficult to deal with. In current clinical practice, hepatoprotective drugs are commonly used to protect the damaged liver. The artificial liver is often used as a replacement treatment for liver failure, but its effectiveness is limited. The aim of this research topic is to reveal the mechanism of liver injury and the molecular target of alleviating liver injury. It is necessary to alleviate liver injury and maintain basic liver function, and avoid liver cancer caused by long-term liver damage. So far, there have been several treatments, such as traditional Chinese medicine, mesenchymal stem cells, small molecule inhibitors, and so on. More therapies need to be discovered to improve the prognosis of patients with liver injury or HCC.
In this Research Topic, we invite investigators to submit Original Research articles as well as Review articles to present new data, review cutting-edge techniques, and develop new ideas to promote these advancements. We are interested in articles that describe basic and clinical research on liver injury and HCC.
Potential subtopics include, but are not limited to the following:
1. Recent advances in acute/chronic liver injury and HCC;
2. New mechanism of acute/chronic liver injury and HCC;
3. New drug/treatment for acute/chronic liver injury and HCC;
4. New advances in metabolic reprogramming, immune infiltration, inflammatory response in acute/chronic liver injury and HCC;
5. New advances in molecular signaling crosstalk between parenchymal and nonparenchymal cells in acute/chronic liver injury and HCC;
6. Clinical application of therapeutic strategy in treating liver injury and HCC.
Keywords: Therapy; Liver injury; HCC; Mechanism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
