About this Research Topic
Here, we aim to assemble primary research articles and reviews highlighting some of the most exciting developments in this area. However, Original Research, Systematic Review, Review, Mini Review, Methods, Hypothesis and Theory, Perspective, Clinical Trials, Case reports, Conceptual Analysis, Data reports, Technology, and Code articles will be accepted in this research topic.
Specific examples of areas of research that would be highly suitable for the research topic include (but are not limited to):
• Methods to link TCRs with their cognate antigens (throughput, validation, etc)
• Molecular and/or structural insight into TCR-pMHC interactions
• Computational methods for learning the sequence determinants of TCR specificity
• Engineered cellular therapies based on TCR specificity - neoantigen directed T cell therapies in cancer (personalized or not) / Treg cell therapies in autoimmunity
• T-cell directed vaccination strategies, e.g. for cancer immunotherapy
• Soluble TCR approaches based on TCRs-pMHC data
• TCR repertoires as high-dimensional immunodiagnostics
• TCR specificity discovery as a way to identify 'holes' in pathogen immune evasion
Keywords: TCR sequences, T cells, pathogen immune evasion
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.