Frontiers | Harnessing TCR - Peptide/MHC binding Specificity to Tackle Disease

Harnessing TCR - Peptide/MHC binding Specificity to Tackle Disease

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ORIGINAL RESEARCH

Published on 02 Oct 2024

TCRcost: a deep learning model utilizing TCR 3D structure for enhanced of TCR–peptide binding

Fan Li
Xinyang Qian
Xiaoyan Zhu
Xin Lai
Xuanping Zhang
Jiayin Wang

TCRcost: a deep learning model utilizing TCR 3D structure for enhanced of TCR–peptide binding

doi 10.3389/fgene.2024.1346784

702 views
1 citation

ORIGINAL RESEARCH

Published on 16 Aug 2024

TCR-H: explainable machine learning prediction of T-cell receptor epitope binding on unseen datasets

Rajitha Rajeshwar T.
Omar N. A. Demerdash
Jeremy C. Smith

TCR-H: explainable machine learning prediction of T-cell receptor epitope binding on unseen datasets

doi 10.3389/fimmu.2024.1426173

1,752 views
1 citation

REVIEW

Published on 12 Dec 2023

Utilizing immunogenomic approaches to prioritize targetable neoantigens for personalized cancer immunotherapy

Ravi K. Shah
Erin Cygan
Tanya Kozlik
Alfredo Colina
Anthony E. Zamora

Utilizing immunogenomic approaches to prioritize targetable neoantigens for personalized cancer immunotherapy

doi 10.3389/fimmu.2023.1301100

3,380 views
1 citation

ORIGINAL RESEARCH

Published on 20 Nov 2023

Overall avidity declines in TCR repertoires during latent CMV but not EBV infection

Barbara Couturaud
Bastien Doix
Laura Carretero-Iglesia
Mathilde Allard
Sylvain Pradervand
Michael Hebeisen
Nathalie Rufer

Overall avidity declines in TCR repertoires during latent CMV but not EBV infection

doi 10.3389/fimmu.2023.1293090

1,588 views

REVIEW

Published on 17 Nov 2023

Structural basis for T cell recognition of cancer neoantigens and implications for predicting neoepitope immunogenicity

Roy A. Mariuzza
Daichao Wu
Brian G. Pierce

Structural basis for T cell recognition of cancer neoantigens and implications for predicting neoepitope immunogenicity

doi 10.3389/fimmu.2023.1303304

4,858 views
8 citations

TECHNOLOGY AND CODE

Published on 25 Oct 2023

tidytcells: standardizer for TR/MH nomenclature

Yuta Nagano
Benjamin Chain

tidytcells: standardizer for TR/MH nomenclature

doi 10.3389/fimmu.2023.1276106

1,552 views
2 citations

ORIGINAL RESEARCH

Published on 16 Oct 2023

Proper development of long-lived memory CD4 T cells requires HLA-DO function

Nianbin Song
Robin A. Welsh
Scheherazade Sadegh-Nasseri

Proper development of long-lived memory CD4 T cells requires HLA-DO function

doi 10.3389/fimmu.2023.1277609

1,165 views

ORIGINAL RESEARCH

Published on 04 Sep 2023

Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice

Dawei Chen
Dimitri Kakabadse
Sigal Fishman
Hadas Weinstein-Marom
Joanne Davies
Joanne Boldison
Terri C. Thayer
Li Wen
Gideon Gross
F. Susan Wong

Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice

doi 10.3389/fimmu.2023.1227133

2,197 views
2 citations

ORIGINAL RESEARCH

Published on 15 Aug 2023

Large-scale template-based structural modeling of T-cell receptors with known antigen specificity reveals complementarity features

Dmitrii S. Shcherbinin
Vadim K. Karnaukhov
Ivan V. Zvyagin
Dmitriy M. Chudakov
Mikhail Shugay

Large-scale template-based structural modeling of T-cell receptors with known antigen specificity reveals complementarity features

doi 10.3389/fimmu.2023.1224969

2,015 views
2 citations

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