About this Research Topic
Single cell technologies including Genomics and Proteomics are rapidly evolving and these technologies are allowing intricate dissection of biological mechanisms occurring at the cellular level including providing important spatial context. These approaches have led to new signaling hypotheses and provided novel avenues for potential therapeutic intervention. In addition to advances in each of these single cell technologies as standalone methodologies we are also witnessing an increase in multi-omics techniques, where combining technologies offers a powerful glimpse into intracellular signaling mechanisms and disease pathology.
Here, we delve into some of the technologies being advanced in this field, and the contributions this is making to our understanding of immunological and cancer immunological disease pathogenesis. This edition will cover technological advances, how these have impacted biological profiles related to immunological disease, and how the software and algorithmic generations is contributing to optimizing data interpretation. We are inviting many experts from the field to contribute their latest findings.
There are many new technological advances in the single cell field in all Omics disciplines. These have led to new discoveries in terms of how the immune system is orchestrated to work against cancer, and infections, and also how it is dysregulated in aetiologies such as autoimmune disease. Here our goal is to focus on describing these emerging technological advances and their impact on interrogating immunological disease biology.
We are interested in manuscripts that consist of either original scientific research, or reviews, that cover technologies associated with single cell characterization of immunological mechanisms in the context of disease, auto-immunity, cancer, or cellular homeostasis in aging. These tools can include epigenomic, transcriptomic, and proteomic technologies and software-related protocols.
We would like to best understand and highlight both the advances in these fields but also, the remaining challenges as they pertain to the extraction of cellular material, and preservation of modifications, both at the genomic, transcriptomic, and translational levels, in addition to challenges and solutions related to data interpretation.
Here, we delve into some of the technologies being advanced in this field, and the contributions this is making to our understanding of immunological and cancer immunological disease pathogenesis. This edition will cover technological advances, how these have impacted biological profiles related to immunological disease, and how the software and algorithmic generations is contributing to optimizing data interpretation. We are inviting many experts from the field to contribute their latest findings.
There are many new technological advances in the single cell field in all Omics disciplines. These have led to new discoveries in terms of how the immune system is orchestrated to work against cancer, and infections, and also how it is dysregulated in aetiologies such as autoimmune disease. Here our goal is to focus on describing these emerging technological advances and their impact on interrogating immunological disease biology.
We are interested in manuscripts that consist of either original scientific research, or reviews, that cover technologies associated with single cell characterization of immunological mechanisms in the context of disease, auto-immunity, cancer, or cellular homeostasis in aging. These tools can include epigenomic, transcriptomic, and proteomic technologies and software-related protocols.
We would like to best understand and highlight both the advances in these fields but also, the remaining challenges as they pertain to the extraction of cellular material, and preservation of modifications, both at the genomic, transcriptomic, and translational levels, in addition to challenges and solutions related to data interpretation.
Keywords: Single Cell, Omics, Proteomics, Next Generation Sequencing, ATAC-Seq, Immunology, Cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
