About this Research Topic
In this Research Topic, our purpose is to compile the latest developments in our understanding of molecular and cellular mechanisms underlying pre- and postsynaptic assembly, specification of synaptic adhesion pathways, presynaptic neurotransmitter release and postsynaptic receptor trafficking. In addition, non-neuronal cell processes involved in dismantling and eliminating synapses and relevant neural circuits will be covered. Clinical implications of this research topic will be considered, emphasizing the importance of these basic neuroscience research activities for translational and therapeutic applications. This includes literature describing recent methodologies for probing key issues regarding assembly/disassembly of synapses and circuits as well as primary research articles that provide critical insights into these fundamental questions in various model systems and experimental preparations.
Keywords: synapse, neural circuit, synapse assembly, synapse formation, synapse elimination
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