About this Research Topic
Durable cell cycle arrest in previously replication-competent cells in the absence of cell death is a hallmark of cellular senescence; in this state cells are no longer proliferating, but remain metabolically active. Importantly, senescent cells exhibit a newly acquired phenotype which includes secretion of a senescent secretome, also known as senescence associated secretory phenotype (SASP), which is capable of inducing senescence in neighboring cells and altering local tissue environment.
Cellular senescence was once thought to primarily serve as a protective response to eliminate malignant cells that survived apoptosis, promote wound healing and tissue remodeling. However, it is now becoming clear that senescent cells are also a significant contributing factor to the oral and craniofacial complex. Clearly, cellular senescence represents a two-edged sword as it relates to health and disease.
In light of the rapid expansion of the field of cellular senescence to health and disease, in general, and the pathogenesis of oral and craniofacial disease, in particular, we propose this Research Topic to bring increased awareness to the diverse causes and effects of cellular senescence. The objective of this Research Topic is to curate a series of reviews, commentaries and research articles on the role of cellular senescence in all aspects of oral health and disease.
Cellular senescence was once thought to primarily serve as a protective response to eliminate malignant cells that survived apoptosis, promote wound healing and tissue remodeling. However, it is now becoming clear that senescent cells are also a significant contributing factor to the oral and craniofacial complex. Clearly, cellular senescence represents a two-edged sword as it relates to health and disease.
In light of the rapid expansion of the field of cellular senescence to health and disease, in general, and the pathogenesis of oral and craniofacial disease, in particular, we propose this Research Topic to bring increased awareness to the diverse causes and effects of cellular senescence. The objective of this Research Topic is to curate a series of reviews, commentaries and research articles on the role of cellular senescence in all aspects of oral health and disease.
Keywords: Secretome, SASP, Senescence Associated Secretory Phenotype, Cellular Senescence, Oral Disease, Oral and Craniofacial Disease, Pathogenesis, Aging and Dental Medicine
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