About this Research Topic
Neurodegenerative diseases, which include Alzheimer's disease, Parkinson's disease, Huntington's disease, and ALS, are disorders that result in the progressive loss of function and death of nerve cells in the brain and spinal cord. Despite extensive research, the underlying mechanisms and pathophysiology of these diseases are still elusive. Since the pathogenesis mechanisms of neurodegenerative diseases are multifactorial, systematic analysis is essential. Recent advances in omics approaches such as transcriptomics, proteomics, metabolomics, and bioinformatics have provided powerful tools for integrative analysis by investigating the global scale of molecular changes that occur in neurodegenerative diseases and identifying biomarkers and potential therapeutic targets. This research topic aims to present the latest advances in omics approaches and the applications of omics approaches to studying neurodegenerative diseases.
The problem that this Research Topic aims to address is the lack of a comprehensive understanding of the molecular mechanisms underlying neurodegenerative diseases. Omics technologies such as transcriptomics, proteomics, and metabolomics provide a powerful tool for a comprehensive and systematic understanding of the pathogenesis mechanisms. Especially, multi-omic, cell-type-specific, single-cell or spatial analysis will further facilitate it. To achieve this goal, researchers can employ cutting-edge technologies such as single-cell RNA sequencing, spatial transcriptomics, cell-type-specific proteome analysis, single-cell proteome analysis, spatial proteome analysis, cell-type-specific metabolomic analysis, and spatial metabolomic analysis to investigate the molecular changes that occur in specific cell types or specific cells within the brain and spinal cord. These approaches can provide insights into the molecular mechanisms underlying neurodegeneration, identify new therapeutic targets, and develop personalized treatments. Furthermore, the integration of omics data with clinical and pathological information can help identify biomarkers for early diagnosis and monitoring of disease progression, leading to better patient outcomes. In summary, the application of omics technologies in a cell-type-specific and single-cell manner has the potential to provide a more comprehensive understanding of the molecular mechanisms underlying neurodegeneration and could lead to the development of effective treatments for these debilitating diseases.
The scope of this Research Topic is the application of omics technologies to understand the pathogenesis mechanisms of neurodegenerative diseases or to discover biomarkers for neurodegenerative diseases using omics technologies as follows, but not limited to:
- A comprehensive analysis by combining multiple omics technologies
- Cell-type specific omics analysis
- Single-cell omics analysis
- Special omics analysis
- Bioinformatic analysis
- General omics analysis
- Identification of noncanonical RNAs or proteins
- Identification of post-translational modifications
- Development of omics technologies that can be applied to study neurodegenerative diseases
The problem that this Research Topic aims to address is the lack of a comprehensive understanding of the molecular mechanisms underlying neurodegenerative diseases. Omics technologies such as transcriptomics, proteomics, and metabolomics provide a powerful tool for a comprehensive and systematic understanding of the pathogenesis mechanisms. Especially, multi-omic, cell-type-specific, single-cell or spatial analysis will further facilitate it. To achieve this goal, researchers can employ cutting-edge technologies such as single-cell RNA sequencing, spatial transcriptomics, cell-type-specific proteome analysis, single-cell proteome analysis, spatial proteome analysis, cell-type-specific metabolomic analysis, and spatial metabolomic analysis to investigate the molecular changes that occur in specific cell types or specific cells within the brain and spinal cord. These approaches can provide insights into the molecular mechanisms underlying neurodegeneration, identify new therapeutic targets, and develop personalized treatments. Furthermore, the integration of omics data with clinical and pathological information can help identify biomarkers for early diagnosis and monitoring of disease progression, leading to better patient outcomes. In summary, the application of omics technologies in a cell-type-specific and single-cell manner has the potential to provide a more comprehensive understanding of the molecular mechanisms underlying neurodegeneration and could lead to the development of effective treatments for these debilitating diseases.
The scope of this Research Topic is the application of omics technologies to understand the pathogenesis mechanisms of neurodegenerative diseases or to discover biomarkers for neurodegenerative diseases using omics technologies as follows, but not limited to:
- A comprehensive analysis by combining multiple omics technologies
- Cell-type specific omics analysis
- Single-cell omics analysis
- Special omics analysis
- Bioinformatic analysis
- General omics analysis
- Identification of noncanonical RNAs or proteins
- Identification of post-translational modifications
- Development of omics technologies that can be applied to study neurodegenerative diseases
Keywords: Neurodegenerative disease, Proteomics, Metabolomics, Bioinformatics, Mass Spectrometry
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