Neurological diseases pose a significant health challenge as they account for the second leading cause of death worldwide and also the primary cause of disability across the globe. The major neurological disorders (NDs) considered in the global burden of diseases (GBD) include stroke, Multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Autism Spectrum Disorders (ASD), Schizophrenia, Epilepsy, and headache disorders. Many neurological insults lead to cognitive impairments and personality changes severely impacting the quality of life.
Neuropathologies are substantially being recognized as multifaceted, with the role of inflammation, oxidative stress, metabolic alterations, autophagy, and apoptosis as integral players from disease development to progression. Many pieces of evidence affirm these pathways have an impact on neuronal networks, synaptic signaling, and cognitive impairment in patients with different NDs.
The current Research Topic aims to collect articles focusing on cellular, metabolic, lipid, and molecular alterations in synaptic proteins, their role and mechanisms in neurological diseases, and cross-talk of one or more of these synaptic proteins in different diseases ranging from neurodevelopmental disorders to neurodegenerative disorders. The goal is to address the role of synaptic proteins in neurological diseases.
Although advances in understanding the interactions, mechanisms, and players of synapses are increasing, therapies targeting the synaptic proteins are insufficiently addressed. Revolutionary technologies like MACE, single cell, spatial transcriptomic, and other omics technologies have made it possible to understand biology in next-generation terms. Advances in understanding the role, implication, and alterations in neuronal synapses can help in the development of targeted therapies. In addition, studying the cross-talk of a few candidates in one or more of the neuropathologies will aid in the development of synergistic approaches. Also, many patients with NDs have an inferior quality of life, especially due to cognitive defects, dementia, and paralysis. More understanding in the field of synaptic biology can improve rehabilitation approaches that will not only enhance health but also significantly decrease the health burden of the patients. As synaptic therapy-directed approaches are only at an early stage, research on such therapies and mechanisms will be of great interest.
In this Research Topic, we encourage researchers to submit work related to synaptic protein functions and dysfunctions at the level of behavioral, anatomical, electrophysiological, and genetics, in the context of one or several of the different neuropathological conditions including but not limited to the following:
- Stroke, Multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Autism Spectrum Disorders (ASD), Schizophrenia, Epilepsy.
- Novel therapeutic strategies in treating or reducing phenotypic deficits at different levels.
We welcome the submission of original research articles, reviews, mini-reviews, systemic reviews, and perspective articles.
Keywords:
Neurological diseases, Stroke, Schizophrenia, Epilepsy, Presynaptic proteins, Multiple sclerosis, Alzheimer's disease, Parkinson disease, Autism spectrum disorder, Postsynaptic proteins, Synapse
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Neurological diseases pose a significant health challenge as they account for the second leading cause of death worldwide and also the primary cause of disability across the globe. The major neurological disorders (NDs) considered in the global burden of diseases (GBD) include stroke, Multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Autism Spectrum Disorders (ASD), Schizophrenia, Epilepsy, and headache disorders. Many neurological insults lead to cognitive impairments and personality changes severely impacting the quality of life.
Neuropathologies are substantially being recognized as multifaceted, with the role of inflammation, oxidative stress, metabolic alterations, autophagy, and apoptosis as integral players from disease development to progression. Many pieces of evidence affirm these pathways have an impact on neuronal networks, synaptic signaling, and cognitive impairment in patients with different NDs.
The current Research Topic aims to collect articles focusing on cellular, metabolic, lipid, and molecular alterations in synaptic proteins, their role and mechanisms in neurological diseases, and cross-talk of one or more of these synaptic proteins in different diseases ranging from neurodevelopmental disorders to neurodegenerative disorders. The goal is to address the role of synaptic proteins in neurological diseases.
Although advances in understanding the interactions, mechanisms, and players of synapses are increasing, therapies targeting the synaptic proteins are insufficiently addressed. Revolutionary technologies like MACE, single cell, spatial transcriptomic, and other omics technologies have made it possible to understand biology in next-generation terms. Advances in understanding the role, implication, and alterations in neuronal synapses can help in the development of targeted therapies. In addition, studying the cross-talk of a few candidates in one or more of the neuropathologies will aid in the development of synergistic approaches. Also, many patients with NDs have an inferior quality of life, especially due to cognitive defects, dementia, and paralysis. More understanding in the field of synaptic biology can improve rehabilitation approaches that will not only enhance health but also significantly decrease the health burden of the patients. As synaptic therapy-directed approaches are only at an early stage, research on such therapies and mechanisms will be of great interest.
In this Research Topic, we encourage researchers to submit work related to synaptic protein functions and dysfunctions at the level of behavioral, anatomical, electrophysiological, and genetics, in the context of one or several of the different neuropathological conditions including but not limited to the following:
- Stroke, Multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Autism Spectrum Disorders (ASD), Schizophrenia, Epilepsy.
- Novel therapeutic strategies in treating or reducing phenotypic deficits at different levels.
We welcome the submission of original research articles, reviews, mini-reviews, systemic reviews, and perspective articles.
Keywords:
Neurological diseases, Stroke, Schizophrenia, Epilepsy, Presynaptic proteins, Multiple sclerosis, Alzheimer's disease, Parkinson disease, Autism spectrum disorder, Postsynaptic proteins, Synapse
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.