About this Research Topic
Mitochondria are essential organelles found in most eukaryotic cells that play a crucial role in cellular metabolism, energy production, and signalling pathways. Recent studies have shown that mitochondria are also involved in various disease processes, including cancer. This research topic aims to explore the association between cancer development and mitochondria, particularly genetic alterations in mitochondrial DNA. Advances in sequencing technologies have allowed for the identification of mitochondrial mutations associated with various cancers, providing new insights into the underlying mechanisms of oncogenesis. Additionally, research has revealed that mitochondrial dysfunction can contribute to cancer progression and may serve as a potential therapeutic target for the treatment. This topic is critical for understanding the pathogenesis of cancer and developing new strategies for cancer diagnosis and treatment.
Mitochondria are intracellular organelles involved in energy production, cell metabolism and cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism and nucleic acid metabolism, but also in heart failure, tumor development and metastasis and other diseases. Mutations in mtDNA are commonly found in cancer cells to promote the rewiring of bioenergetics and biosynthesis, various metabolites especially oncometabolites in mitochondria regulate tumor metabolism and progression. Mitochondria have been demonstrated as the target for the treatment for various cancers.
The research topic about mitochondria and mitochondrial genes is an interdisciplinary area that involves various fields of science, including genetics, cell biology, biochemistry, and physiology. The scope of the research includes a wide range of topics related to mitochondria, including their structure, function, regulation, but most importantly their involvement in cancer development. The research topic encompasses a broad range of research methodologies, from in vitro studies using cell lines and animal models to clinical studies in human populations. Overall, the research topic is inclusive of all types of research related to mitochondria and mitochondrial genes and provides an opportunity to advance our understanding of these critical organelles and their roles in cancers.
Bioinformatic studies are welcome, however, these should not be based solely on analysis of publicly available datasets such as TCGA. It is essential to have an independent validation cohort for statistically significant confirmation of the findings communicated.
Mitochondria are intracellular organelles involved in energy production, cell metabolism and cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism and nucleic acid metabolism, but also in heart failure, tumor development and metastasis and other diseases. Mutations in mtDNA are commonly found in cancer cells to promote the rewiring of bioenergetics and biosynthesis, various metabolites especially oncometabolites in mitochondria regulate tumor metabolism and progression. Mitochondria have been demonstrated as the target for the treatment for various cancers.
The research topic about mitochondria and mitochondrial genes is an interdisciplinary area that involves various fields of science, including genetics, cell biology, biochemistry, and physiology. The scope of the research includes a wide range of topics related to mitochondria, including their structure, function, regulation, but most importantly their involvement in cancer development. The research topic encompasses a broad range of research methodologies, from in vitro studies using cell lines and animal models to clinical studies in human populations. Overall, the research topic is inclusive of all types of research related to mitochondria and mitochondrial genes and provides an opportunity to advance our understanding of these critical organelles and their roles in cancers.
Bioinformatic studies are welcome, however, these should not be based solely on analysis of publicly available datasets such as TCGA. It is essential to have an independent validation cohort for statistically significant confirmation of the findings communicated.
Keywords: Cancer, Genetics, Mitochondria, mtDNA
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