About this Research Topic
Cardiovascular disease remains a leading cause of death worldwide, with vascular wall pathology gaining significant attention in recent decades. The understanding of vascular injury, from subclinical stages to clinically evident cardiovascular manifestations, has been substantially enhanced by numerous studies. These studies have shaped preventive strategies and novel therapeutic treatments. Vascular injury is central to the pathogenesis and progression of cardiovascular disease, driven by processes such as endothelial dysfunction, atherosclerosis, and subclinical inflammation. This injury further propagates cardiovascular disease, creating a vicious cycle with severe clinical consequences. Additionally, several systemic diseases, ranging from autoimmune rheumatic diseases to novel entities like COVID-19, directly or indirectly affect the cardiovascular system, resulting in vascular injury through shared underlying mechanisms. Despite advancements, many questions remain unanswered, and novel hypotheses continue to emerge in this complex field.
This research topic aims to unravel the pathophysiological and clinical aspects of vascular injury in vivo or using animal models. It seeks to develop and validate vascular and circulating biomarkers, providing further mechanistic and clinical insights into the role of vascular injury, with a particular emphasis on diagnostics and treatment. The goal is to gather input from basic, translational, and clinical researchers across different specialties to introduce and promote novel concepts and summarize state-of-the-art knowledge.
To gather further insights into the boundaries of vascular injury in systemic diseases, we welcome articles addressing, but not limited to, the following themes:
- Cardiovascular diseases (e.g., acute and chronic coronary syndromes, heart failure, hypertension, diabetes mellitus, and chronic kidney disease).
- Autoimmune rheumatic disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, systemic vasculitis).
- Chronic inflammatory diseases (e.g., psoriasis, inflammatory bowel disease).
- Hematological disorders.
- COVID-19 and other infectious diseases.
This research topic aims to unravel the pathophysiological and clinical aspects of vascular injury in vivo or using animal models. It seeks to develop and validate vascular and circulating biomarkers, providing further mechanistic and clinical insights into the role of vascular injury, with a particular emphasis on diagnostics and treatment. The goal is to gather input from basic, translational, and clinical researchers across different specialties to introduce and promote novel concepts and summarize state-of-the-art knowledge.
To gather further insights into the boundaries of vascular injury in systemic diseases, we welcome articles addressing, but not limited to, the following themes:
- Cardiovascular diseases (e.g., acute and chronic coronary syndromes, heart failure, hypertension, diabetes mellitus, and chronic kidney disease).
- Autoimmune rheumatic disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, systemic vasculitis).
- Chronic inflammatory diseases (e.g., psoriasis, inflammatory bowel disease).
- Hematological disorders.
- COVID-19 and other infectious diseases.
Keywords: vascular injury, cardiovascular disease, hematological disorders, chronic inflammatory diseases, autoimmune rheumatic disorders, COVID-19, infections
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