About this Research Topic
Diabetic retinopathy (DR) was the most common and serious vision threatening complication caused by diabetes mellitus (DM). The global prevalence of DR has been increasing among patients with diabetes. Multiple factors can lead to the occurrence and development of DR, such as O-linked N-acetylglucosamine (O-GlcNAc) modification which displays a strong correlation with DR. Extensive research on the complex pathogenesis of DR has long focused on microvascular dysfunction. Currently, there are many treatment strategies for diabetic retinopathy at the late stage. However, each method has its own limitation and side-effect. As the in-depth study progresses, DR is now also regarded as a neurodegenerative disease at the early stage. Moreover, the related molecular mechanism and prevention are still unclear. Therefore, in the future it is vital to find a new manner to prevent diabetic retinopathy at early stage, such as natural products, nutrients and some drugs delivered through nanotechnology or engineering methods.
This Research Topic aims to explore the role of neurodegeneration in diabetic retinopathy and related mechanism. It also seeks to explore some preventive treatments such as natural products, nutrients or some drugs for diabetic retinopathy. We hope to gain insight from experts across fields, including pharmacology, biochemical nanotechnology and engineering, in order to provide some evidence for future clinical treatment of diabetic retinopathy.
The current Research Topic encourages Original Research, Mini-Review, or other accepted article types relating, but not limited to:
• The role of neurodegeneration in diabetic retinopathy and related molecular mechanism.
• The role of O-GlcNAc modification and related molecular mechanism in diabetic retinopathy-induced neurodegeneration.
• The strategies for preventing neurodegeneration in diabetic retinopathy.
• The prevention or treatment for diabetic retinopathy with some drugs or natural products delivered through nanotechnology or engineering methods.
• The interaction and effect between different types of the cell in the retina during diabetic retinopathy such as photoreceptor, retina pigment epithelium cell and microglial cell by cell line, primary cell culture, 3D culture or organoids methods.
This Research Topic aims to explore the role of neurodegeneration in diabetic retinopathy and related mechanism. It also seeks to explore some preventive treatments such as natural products, nutrients or some drugs for diabetic retinopathy. We hope to gain insight from experts across fields, including pharmacology, biochemical nanotechnology and engineering, in order to provide some evidence for future clinical treatment of diabetic retinopathy.
The current Research Topic encourages Original Research, Mini-Review, or other accepted article types relating, but not limited to:
• The role of neurodegeneration in diabetic retinopathy and related molecular mechanism.
• The role of O-GlcNAc modification and related molecular mechanism in diabetic retinopathy-induced neurodegeneration.
• The strategies for preventing neurodegeneration in diabetic retinopathy.
• The prevention or treatment for diabetic retinopathy with some drugs or natural products delivered through nanotechnology or engineering methods.
• The interaction and effect between different types of the cell in the retina during diabetic retinopathy such as photoreceptor, retina pigment epithelium cell and microglial cell by cell line, primary cell culture, 3D culture or organoids methods.
Keywords: neurodegeneration, O-GlcNAc modification, AMPK, diabetic retinopathy, autophagy, mitochondrial, photoreceptor
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