About this Research Topic
Tyrosine phosphorylation is an essential protein post-translational modification important for several biological functions. Protein tyrosine phosphatases (PTPs) are enzymes that remove phosphate from tyrosine residues and are the counterpart of protein tyrosine kinases (PTKs). However, there are not solely “off” switches for PTPs, as they have been implicated in the regulation of several biological processes such as proliferation, migration, and differentiation. The dysregulation of these processes has a broad implication in several diseases such as cancer, cardiac and autoimmune diseases, diabetes, and inflammation.
PTP1B was the first identified PTP and has a ubiquitous expression. PTP1B is known as a negative regulator of several growth factor receptors such as the Epidermal Growth Factor Receptor and the Insulin Receptor. Besides its role in the regulation of insulin signaling, PTP1B also plays an important role in leptin signaling through dephosphorylation of the kinase JAK2. Accumulating evidence also indicates that PTP1B is involved in cancer, but contrasting findings suggest that it can show both tumor-suppressing and tumor-promoting effects depending on the cellular context. In humans, the PTPN1 gene encodes the PTP1B protein. It is located at chromosome 20q13.1 and this region is known to be amplified in many cancer types including breast cancer, and it is also a region associated with obesity and diabetes. Amplification of this genetic locus has been associated with poor prognosis, progression, and metastases formation of breast cancer. Since PTP1B acts as a positive and a negative regulator of signaling pathways, PTP1B is an interesting therapeutic target.
The goal of this Research Topic is to gain knowledge on the most recent findings about the role of PTP1B in the development of cancer. We aim to publish both pre-clinical and clinical studies that answer unsolved questions on how PTP1B is implicated in the initiation and progression of solid tumors. Researchers are encouraged to describe new substrates of PTP1B that can be used as biomarkers for diagnosis, prognosis, and therapeutic targets of any type of solid tumors.
We welcome state of art reviews, mini-reviews, and original research articles dealing with basic, translational, and clinical studies regarding the role of PTP1B in the initiation and progression of cancer.
PTP1B was the first identified PTP and has a ubiquitous expression. PTP1B is known as a negative regulator of several growth factor receptors such as the Epidermal Growth Factor Receptor and the Insulin Receptor. Besides its role in the regulation of insulin signaling, PTP1B also plays an important role in leptin signaling through dephosphorylation of the kinase JAK2. Accumulating evidence also indicates that PTP1B is involved in cancer, but contrasting findings suggest that it can show both tumor-suppressing and tumor-promoting effects depending on the cellular context. In humans, the PTPN1 gene encodes the PTP1B protein. It is located at chromosome 20q13.1 and this region is known to be amplified in many cancer types including breast cancer, and it is also a region associated with obesity and diabetes. Amplification of this genetic locus has been associated with poor prognosis, progression, and metastases formation of breast cancer. Since PTP1B acts as a positive and a negative regulator of signaling pathways, PTP1B is an interesting therapeutic target.
The goal of this Research Topic is to gain knowledge on the most recent findings about the role of PTP1B in the development of cancer. We aim to publish both pre-clinical and clinical studies that answer unsolved questions on how PTP1B is implicated in the initiation and progression of solid tumors. Researchers are encouraged to describe new substrates of PTP1B that can be used as biomarkers for diagnosis, prognosis, and therapeutic targets of any type of solid tumors.
We welcome state of art reviews, mini-reviews, and original research articles dealing with basic, translational, and clinical studies regarding the role of PTP1B in the initiation and progression of cancer.
Keywords: Protein Tyrosine Phosphatase 1B (PTP1B), cancer, PTP1B inhibitors, PTP1B substrates, signal transduction
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