About this Research Topic
CAR-T cell therapy is a revolutionary form of cancer treatment that uses genetically modified T-cells to target cancer cells. It has shown promising results in the treatment of hematologic malignancies such as lymphoma and leukemia. However, there are still significant challenges to be addressed, such as managing toxicities and improving response rates.
The future of CAR-T cell therapy in hematologic malignancies lies in identifying ways to improve its efficacy and safety. One area of research is developing strategies to enhance the persistence and expansion of CAR-T cells in vivo, which would improve the durability of the response. Another important goal is to identify biomarkers that can predict response to CAR-T cell therapy and the risk of adverse events.
This Research Topic aims to bring together researchers and clinicians to discuss the latest advances in CAR-T cell therapy for hematologic malignancies. We hope that this collection will contribute to a better understanding of the potential of CAR-T cell therapy and inspire further research to improve the lives of patients with hematologic malignancies.
We welcome original research articles, reviews, and commentaries on topics related to, but not limited to:
- the efficacy and safety of CAR-T cell therapy, including preclinical studies, clinical trials, and real-world data.
- new approaches to improving the safety and efficacy of CAR-T cell therapy, such as combination therapies or novel CAR designs
- novel biomarkers that can predict response to CAR-T cell therapy
- the risk of adverse events to CAR-T cell therapy
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
The future of CAR-T cell therapy in hematologic malignancies lies in identifying ways to improve its efficacy and safety. One area of research is developing strategies to enhance the persistence and expansion of CAR-T cells in vivo, which would improve the durability of the response. Another important goal is to identify biomarkers that can predict response to CAR-T cell therapy and the risk of adverse events.
This Research Topic aims to bring together researchers and clinicians to discuss the latest advances in CAR-T cell therapy for hematologic malignancies. We hope that this collection will contribute to a better understanding of the potential of CAR-T cell therapy and inspire further research to improve the lives of patients with hematologic malignancies.
We welcome original research articles, reviews, and commentaries on topics related to, but not limited to:
- the efficacy and safety of CAR-T cell therapy, including preclinical studies, clinical trials, and real-world data.
- new approaches to improving the safety and efficacy of CAR-T cell therapy, such as combination therapies or novel CAR designs
- novel biomarkers that can predict response to CAR-T cell therapy
- the risk of adverse events to CAR-T cell therapy
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Keywords: CAR-T, Immunotherapy, Hematologic Malignancies, Therapy, Leukemia, Lymphoma, Biomarkers
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
