About this Research Topic
Pustular psoriasis (PP), which may occur with concurrent plaque psoriasis, is a rare entity characterized by the presence of sterile pustules that can be localized or generalized. Classically recognized subtypes of pustular psoriasis include generalized pustular psoriasis (GPP), palmoplantar pustular psoriasis (PPP), and Acrodermatitis continua of Hallopeau (ACH). Pustular psoriasis poses multiple diagnostic and management challenges to dermatologists. Moreover, the role of the IL-36 pathway has emerged as a key inflammatory axis in the pathogenic mechanism of PP, particularly GPP, and is driving the development of new treatments for these conditions.
This Research Topic will focus on all forms of pustular psoriasis (generalized pustular psoriasis, palmoplantar pustulosis, Acrodermatitis continua of Hallopeau). We aim to provide an overview of the epidemiology, pathogenesis and immunological mechanisms involved, clinical characteristics, burden of disease, and unmet needs and treatments (current and new therapies). This integrated view aims to enhance our understanding about this rare, but potentially high impactful (GPP, PPP and ACH) or life-threatening (GPP) form of psoriasis.
We welcome the submission of Original Research, Reviews, Mini-reviews and Perspective articles, with specific emphasis on, but not limited to, the following themes:
• Epidemiology of pustular psoriasis
• Update on pustular psoriasis pathogenesis
• Clinical characteristics (cutaneous and extracutaneous manifestations) and clinical assessment
• Immunogenetics of pustular psoriasis
• Immune and cytokine networks in pustular psoriasis
• New therapies for pustular psoriasis
This Research Topic will focus on all forms of pustular psoriasis (generalized pustular psoriasis, palmoplantar pustulosis, Acrodermatitis continua of Hallopeau). We aim to provide an overview of the epidemiology, pathogenesis and immunological mechanisms involved, clinical characteristics, burden of disease, and unmet needs and treatments (current and new therapies). This integrated view aims to enhance our understanding about this rare, but potentially high impactful (GPP, PPP and ACH) or life-threatening (GPP) form of psoriasis.
We welcome the submission of Original Research, Reviews, Mini-reviews and Perspective articles, with specific emphasis on, but not limited to, the following themes:
• Epidemiology of pustular psoriasis
• Update on pustular psoriasis pathogenesis
• Clinical characteristics (cutaneous and extracutaneous manifestations) and clinical assessment
• Immunogenetics of pustular psoriasis
• Immune and cytokine networks in pustular psoriasis
• New therapies for pustular psoriasis
Keywords: Generalized pustular psoriasis, palmoplantar pustulosis, acrodermatitis continua of Hallopeau, IL-36, IL-36-inhibitors
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