About this Research Topic
Pancreatic beta-cells, which are the only cell type that produces and secretes insulin, play a crucial role in glucose homeostasis. The loss of beta-cell function or mass is a key feature of type 2 diabetes. Large-scale beta-cell dedifferentiation, characterized by a significant reduction in beta cell identity genes, suggests a dysfunctional and progenitor-like state. This immature state of beta-cells leads to impaired nutrient-stimulated insulin secretion and contributes to the onset of type 2 diabetes.
However, the exact mechanisms underlying beta-cell dedifferentiation require further investigation. Understanding the pathways that govern and regulate this process is essential for the development of therapies aimed at reversing the loss of identity and/or regenerating functional beta-cells for the treatment of diabetes.
We invite submissions for a special issue focusing on various aspects of beta-cell dedifferentiation, including, but not limited to:
• Molecular mechanisms underlying beta-cell dedifferentiation
• Cellular and molecular pathways involved in beta-cell reprogramming
• Cellular plasticity and regeneration of beta-cells
• The impact of environmental and genetic factors on beta-cell dedifferentiation
• Prevention or reversal of beta-cell dedifferentiation
We welcome original research articles, reviews, and mini-reviews for this special issue. All manuscripts should adhere to the guidelines and standards set by Frontiers in Endocrinology. Each submission will undergo a rigorous peer-review process conducted by experts in the field. We look forward to receiving your contributions to this important area of research.
However, the exact mechanisms underlying beta-cell dedifferentiation require further investigation. Understanding the pathways that govern and regulate this process is essential for the development of therapies aimed at reversing the loss of identity and/or regenerating functional beta-cells for the treatment of diabetes.
We invite submissions for a special issue focusing on various aspects of beta-cell dedifferentiation, including, but not limited to:
• Molecular mechanisms underlying beta-cell dedifferentiation
• Cellular and molecular pathways involved in beta-cell reprogramming
• Cellular plasticity and regeneration of beta-cells
• The impact of environmental and genetic factors on beta-cell dedifferentiation
• Prevention or reversal of beta-cell dedifferentiation
We welcome original research articles, reviews, and mini-reviews for this special issue. All manuscripts should adhere to the guidelines and standards set by Frontiers in Endocrinology. Each submission will undergo a rigorous peer-review process conducted by experts in the field. We look forward to receiving your contributions to this important area of research.
Keywords: β-cell, dedifferentiation, type 2 diabetes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
