About this Research Topic
From decades, natural products have been a significant source of health remedies. The use of nature-oriented, bioactive substances in the development of new drugs and traditional medicine is still the priority of the pharmaceuticals. More than 80% to 85% of people throughout the world rely on traditional medicine (TM), as their primary form of healthcare. The easily available TM, mostly herbal products prepared from whole herbs or their extracts, have a significant economic role in many Asian, African, American, and European nations. Therefore, it has become urgent to increase the TM and its constituents' quality, safety, and effectiveness. This can only be accomplished by scientifically validating the lead compounds in TM's chemical foundation and their mode of action. Thanks to the advanced technologies and equipment’s which now has made it easy to create the scaffolds of natural products in the lab, saving a great deal of time as compared to isolating the natural product from its source.
Within the process of scientific validation of TM and their synthetic analogs to be a potential candidate for being developed as high quality Pharmaceutical products, which may provide significant solutions to the growing global health challenges that include infectious and chronic inflammatory diseases, various kinds of cancers, aging societies and rising healthcare costs. This Special Issue invites original research and review articles on the isolation of bioactive molecules from all sources of natural products or their synthetic scaffolds. Emphasis is placed on describing the full range of scientific studies, including isolation, synthesis and structure elucidation, bioactivity screening of compounds, and identification of drug lead compounds such as antimicrobials, anti-inflammatory, anti-diabetic and anti-cancers.
The topic of this Special Issue is intended to cover scientific and experimental data, as well as information on natural or synthetic compounds, in directions related to the following:
• Capacity of medicinal substances, which have been examined in vitro/ in vivo or in-silico, against pathogenic microbes;
• Mode of action of these medicinal compounds and the basic mechanisms by which natural products function or act;
• Natural products derived with efficient bioactivities;
• Synthetic compounds with potential bioactivities；
• Biomolecules derived from natural products or synthesized used in experimental or clinical studies.
Within the process of scientific validation of TM and their synthetic analogs to be a potential candidate for being developed as high quality Pharmaceutical products, which may provide significant solutions to the growing global health challenges that include infectious and chronic inflammatory diseases, various kinds of cancers, aging societies and rising healthcare costs. This Special Issue invites original research and review articles on the isolation of bioactive molecules from all sources of natural products or their synthetic scaffolds. Emphasis is placed on describing the full range of scientific studies, including isolation, synthesis and structure elucidation, bioactivity screening of compounds, and identification of drug lead compounds such as antimicrobials, anti-inflammatory, anti-diabetic and anti-cancers.
The topic of this Special Issue is intended to cover scientific and experimental data, as well as information on natural or synthetic compounds, in directions related to the following:
• Capacity of medicinal substances, which have been examined in vitro/ in vivo or in-silico, against pathogenic microbes;
• Mode of action of these medicinal compounds and the basic mechanisms by which natural products function or act;
• Natural products derived with efficient bioactivities;
• Synthetic compounds with potential bioactivities；
• Biomolecules derived from natural products or synthesized used in experimental or clinical studies.
Keywords: Natural compounds, Synthetic compounds, Structure elucidation, chronic diseases, Inflammation, cancer, mechanisms
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