Advanced Microfluidics for Synthetic Biology and/or Biomedical Applications

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About this Research Topic

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Background

Advanced microfluidics with multi-modal biosensing technologies have become increasingly popular in the BioMEMS community for synthetic biology and/or biomedical applications. The advanced technologies in microfluidics include improvements on traditional lab-on-chip (LOC), point-of-care (POC), organ-on-chip, programmable microfluidics, and recently developed lab-at-home (L@H) techniques (advanced BioMEMS technologies compatible with smart devices for daily usage at home). Advanced microfluidics provides a diversified selection of transducers, i.e. biomechanical, bioelectrical, optical, and chemical biosensors of specific targets, to implant and integrate into microsystems.

The goal of this collection is to address innovations and improvements of technologies in synthetic biology and biomedical applications through advanced microfluidics. This Research Topic provides an opportunity for researchers to communicate their latest findings and promote interdisciplinary collaboration to enhance technology development as well as to expand applications to areas such as building artificial cells, re-arranging living cells, constructing engineered cells to achieve bioinformatics, performing physiological studies, achieving biocomputing functions, and fabricating miniaturized experimental platform for biomedical applications.

The specific themes of this Research Topic focus on advanced microfluidics, integrating multi-modal sensors/transducers and programmable microfluidics for advanced biofabrication processes. Topics and technologies include but not limited to:

• Stereolithography
• Additive manufacturing for 3D microfluidics
• 4D printing techniques
• Programmable microfluidics with active and/or passive mechanisms
• Single cell and/or cell cluster patterning
• Cellular level and/or sub-cellular level biosensing
• in vitro organ-on-chip models
• Synthetic biology associated techniques
• Smart devices interface
• Plasmonic nanostructures for surface-enhanced Raman spectroscopy
• Machine learning or artificial intelligence assisted processes

Authors are encouraged to submit manuscripts covering topics and techniques related to advanced microfluidics in synthetic biology and biomedical applications.

Keywords: Lab-on-chip, MEMS, microsystems, Lab-at-home, Organ-on-chip, Programmable microfluidics, Biosensors, SERS/TERS, Synthetic biology, 3D/4D printing, Biofabrication, Biomedical devices

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