About this Research Topic
The healing of full-thickness skin wounds in adults occurs through a reparative rather than a regenerative process, resulting in a fibrotic tissue deprived of appendages and functionality. Despite the constant advances in attaining more complete healing, effective strategies capable of true skin regeneration are still lacking.
Seminal works on scarless healing in fetal mammals or regenerative model organisms, alongside insights into hair follicle biology, epidermal stem cells, and fibroblast heterogeneity, have identified some of the key cells and molecules involved in skin regeneration. However, future successes in complete skin regeneration will require further advances in the mechanistic basis of healthy regeneration and the translation of that knowledge into innovative technological solutions.
The field of tissue engineering has provided important cues on the potential of relevant tools – stem cells, bioactive molecules, and biomaterials – for improving cutaneous healing. Moreover, it has revealed the benefits as well as the shortcomings of different approaches in the treatment of acute and chronic wounds.
The manuscripts to be included in this research topic will focus on recent developments in skin regeneration from basic to translational research with an emphasis on new knowledge of the biology of regenerative processes in skin, application of cell-based therapies, and innovative tissue engineering approaches with modes of action linked to known healing mechanisms.
Topic Editors declare no conflict of interest.
Seminal works on scarless healing in fetal mammals or regenerative model organisms, alongside insights into hair follicle biology, epidermal stem cells, and fibroblast heterogeneity, have identified some of the key cells and molecules involved in skin regeneration. However, future successes in complete skin regeneration will require further advances in the mechanistic basis of healthy regeneration and the translation of that knowledge into innovative technological solutions.
The field of tissue engineering has provided important cues on the potential of relevant tools – stem cells, bioactive molecules, and biomaterials – for improving cutaneous healing. Moreover, it has revealed the benefits as well as the shortcomings of different approaches in the treatment of acute and chronic wounds.
The manuscripts to be included in this research topic will focus on recent developments in skin regeneration from basic to translational research with an emphasis on new knowledge of the biology of regenerative processes in skin, application of cell-based therapies, and innovative tissue engineering approaches with modes of action linked to known healing mechanisms.
Topic Editors declare no conflict of interest.
Keywords: skin regeneration, scarless healing, skin appendages, translational tissue engineering, chronic wounds, stem cells, bioactive molecules, stimuli-responsive scaffolds, cell therapy
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