About this Research Topic
Older cancer patients are frequently excluded from clinical trials due to the concern about toxicity. Chronologically older cancer patients may not receive curative treatment especially when it involves multi-modality such as surgery and radiotherapy or chemotherapy and radiotherapy even when they are physically fit. As there is a paucity of data on older cancer patients, clinicians are often faced with a difficult choice on how to manage those patients who have many co-morbidities.
As an international research organization dedicated to the care of older cancer patients, minorities, and women, the International Geriatric Radiotherapy Group would like to investigate the pattern of care across the world on the specific topic of multi-modality treatment for older cancer patients. The primary goal of our Research Topic is to assess older cancer patients' tolerance to a multimodality approach for cure or for palliation in light of new modality treatments such as targeted agents or immunotherapy which may improve outcome and toxicity in selected patients. The underlying molecular biology rationale for such an approach may also lead to new paradigms to improve the quality of care. The secondary goal of the collection is to assess treatment outcomes such as survival, disease-free survival, and loco-regional control of older cancer patients compared to younger ones.
All articles reporting on the outcome of older cancer patients defined as 70 years old or above receiving more than one treatment for curative or palliative intent are welcomed. The rationale for such a treatment based on pre-clinical or clinical data which may lead to a better outcome for those patients is also encouraged. Basic sciences highlighting potential combined modalities to decrease cancer treatment toxicity which may be better tolerated by older patients may be considered. The following types of articles are accepted: Original articles, clinical reviews, meta-analyses, perspectives, and hypotheses. Case reports may be accepted if they highlight an innovative approach to treatment.
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
As an international research organization dedicated to the care of older cancer patients, minorities, and women, the International Geriatric Radiotherapy Group would like to investigate the pattern of care across the world on the specific topic of multi-modality treatment for older cancer patients. The primary goal of our Research Topic is to assess older cancer patients' tolerance to a multimodality approach for cure or for palliation in light of new modality treatments such as targeted agents or immunotherapy which may improve outcome and toxicity in selected patients. The underlying molecular biology rationale for such an approach may also lead to new paradigms to improve the quality of care. The secondary goal of the collection is to assess treatment outcomes such as survival, disease-free survival, and loco-regional control of older cancer patients compared to younger ones.
All articles reporting on the outcome of older cancer patients defined as 70 years old or above receiving more than one treatment for curative or palliative intent are welcomed. The rationale for such a treatment based on pre-clinical or clinical data which may lead to a better outcome for those patients is also encouraged. Basic sciences highlighting potential combined modalities to decrease cancer treatment toxicity which may be better tolerated by older patients may be considered. The following types of articles are accepted: Original articles, clinical reviews, meta-analyses, perspectives, and hypotheses. Case reports may be accepted if they highlight an innovative approach to treatment.
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Keywords: older, cancer patients, multimodality, vulnerable, toxicity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
