About this Research Topic
In the intricate landscape of immunology, myeloid cells such as dendritic cells play a pivotal role as conduits for initiating specific immune responses. These professional antigen-presenting cells are essential for recognizing, ingesting, and presenting pathogenic antigens to T-cells, thereby orchestrating tailored immune defenses. However, pathogens have evolved mechanisms to circumvent these immune responses, notably through strategies that induce cell death in these crucial cells.
This research topic aims to decipher how different pathogens manipulate cell death pathways like pyroptosis, apoptosis, and necroptosis to impair immune functions in antigen-presenting cells. Understanding these mechanisms may reveal novel therapeutic targets or strategies to enhance immune response efficacy. By investigating how antigen-presenting cells can avoid cell death or manage hyperactivation in response to inflammasome activation, researchers can potentially uncover crucial adaptations that preserve the cell's antigen-presenting capabilities.
To gather further insights into these complex interactions, we welcome articles addressing, but not limited to, the following themes:
- Mechanisms pathogens employ to trigger cell death in antigen-presenting cells.
- Strategies by which antigen-presenting cells evade cell death induced by pathogens.
- The impact of inhibiting specific cell death pathways on enhancing pathogen-specific immune responses.
- Influence of cell death forms on the ability of antigen-presenting cells to stimulate immune reactions.
- The shaping of immune responses through pathogen-induced cell death pathways.
- APC reactions to DAMPs from necrotic cells during sterile inflammation.
- Key receptors and signaling pathways in APCs for different cell death modalities.
This multifaceted approach aims to provide a comprehensive understanding of the dynamic interplay between cell death and immune regulation, potentially offering new insights into both pathogen defense and immune therapy optimization.
This research topic aims to decipher how different pathogens manipulate cell death pathways like pyroptosis, apoptosis, and necroptosis to impair immune functions in antigen-presenting cells. Understanding these mechanisms may reveal novel therapeutic targets or strategies to enhance immune response efficacy. By investigating how antigen-presenting cells can avoid cell death or manage hyperactivation in response to inflammasome activation, researchers can potentially uncover crucial adaptations that preserve the cell's antigen-presenting capabilities.
To gather further insights into these complex interactions, we welcome articles addressing, but not limited to, the following themes:
- Mechanisms pathogens employ to trigger cell death in antigen-presenting cells.
- Strategies by which antigen-presenting cells evade cell death induced by pathogens.
- The impact of inhibiting specific cell death pathways on enhancing pathogen-specific immune responses.
- Influence of cell death forms on the ability of antigen-presenting cells to stimulate immune reactions.
- The shaping of immune responses through pathogen-induced cell death pathways.
- APC reactions to DAMPs from necrotic cells during sterile inflammation.
- Key receptors and signaling pathways in APCs for different cell death modalities.
This multifaceted approach aims to provide a comprehensive understanding of the dynamic interplay between cell death and immune regulation, potentially offering new insights into both pathogen defense and immune therapy optimization.
Keywords: cell death, dendritic cells, antigen-presenting cells, inflammasome, pyroptosis, DAMPs
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
