About this Research Topic
Many diseases including allergic, autoinflammatory and autoimmune disorders, are immunodysregulatory in nature. Their emergence reflects a fundamental disruption of normative mechanisms that restrain untoward immune responses. One key mechanism involves CD4+CD25+Foxp3+ regulatory T cells (Treg cells), which enforce peripheral immunological tolerance to self-antigens, commensal flora, and innocuous foreign antigens. Elucidating mechanisms that control Treg cell function, transcriptome, and metabolism are of pivotal importance to the restoration of tolerance in diseases of chronic inflammation and autoimmunity.
The scope of this Research Topic is to gather a comprehensive list of articles related to the role of Foxp3 in Treg transcriptome and Treg cell metabolism. The Research Topic will cover various aspects of Tregs ranging from basic research with metabolism and epigenetics and translational research.
The scope of this Research Topic is to gather a comprehensive list of articles related to the role of Foxp3 in Treg transcriptome and Treg cell metabolism. The Research Topic will cover various aspects of Tregs ranging from basic research with metabolism and epigenetics and translational research.
We welcome the submission of Original Research Articles, Reviews, and Mini-reviews, including but not limited to the following topics:
• Role of metabolism in Treg induction, proliferation, differentiation, immune regulation, and apoptosis.
• Role of Foxp3 and his partner in Treg cells metabolism
• Role of Foxp3 and Treg cell metabolism in tissue-Tregs which regulate local homeostasis.
• Basic and translational research on Treg cells metabolism
• Current understanding of the role of Treg metabolism in autoimmunity, infection, or cancers
• Current understanding of how the microenvironment shapes Treg metabolism at the site of inflammation/tumor site
• Novel mechanisms and/or molecules determining Treg metabolism
The scope of this Research Topic is to gather a comprehensive list of articles related to the role of Foxp3 in Treg transcriptome and Treg cell metabolism. The Research Topic will cover various aspects of Tregs ranging from basic research with metabolism and epigenetics and translational research.
The scope of this Research Topic is to gather a comprehensive list of articles related to the role of Foxp3 in Treg transcriptome and Treg cell metabolism. The Research Topic will cover various aspects of Tregs ranging from basic research with metabolism and epigenetics and translational research.
We welcome the submission of Original Research Articles, Reviews, and Mini-reviews, including but not limited to the following topics:
• Role of metabolism in Treg induction, proliferation, differentiation, immune regulation, and apoptosis.
• Role of Foxp3 and his partner in Treg cells metabolism
• Role of Foxp3 and Treg cell metabolism in tissue-Tregs which regulate local homeostasis.
• Basic and translational research on Treg cells metabolism
• Current understanding of the role of Treg metabolism in autoimmunity, infection, or cancers
• Current understanding of how the microenvironment shapes Treg metabolism at the site of inflammation/tumor site
• Novel mechanisms and/or molecules determining Treg metabolism
Keywords: Treg cells metabolism, Foxp3, regulatory T cell, chronic inflammation and autoimmunity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
