About this Research Topic
According to the World Health Organization, the overuse and misuse of antibiotics are reflected in the emergence of resistance, being a threat to global health security. Antimicrobial resistance coupled with the lack of antibiotics effective against resistant bacteria leads to increased mortality, the need for medical assistance, and the cost of treating these infections.
Since the first use in 1996 by John E. McGowan Jr. and Dale N. Gerding the term “Antimicrobial Stewardship” (AMS) has grown exponentially in recent years. The objective was to highlight antimicrobials as a precious and non-renewable resource, using a concept that encompassed rational use, moving away from the concept of cost containment, which had prevailed until then.
Choosing the optimal antibiotic dose includes the pathogen’s minimum inhibitory concentration, site, and severity of infection; also, the patient volume of distribution, renal clearance, weight, and organ support should be considered. Application of pharmacokinetic/pharmacodynamic (PK/PD) concepts in antimicrobial prescription are a stone in AMS programs.
This Research Topic proposes a set of articles to highlight the importance of PK/PD:
- The importance of PK/PD on antimicrobial stewardship
- How TDM can improve antimicrobial stewardship?
- Designing the optimal dose of aminoglycosides in gram-negative infections.
- Vancomycin TDM for every patient? Breaking rules.
- Beta-lactam TDM, the next barrier to cross.
- Achieving optimal antimicrobial dose in ICU care.
Since the first use in 1996 by John E. McGowan Jr. and Dale N. Gerding the term “Antimicrobial Stewardship” (AMS) has grown exponentially in recent years. The objective was to highlight antimicrobials as a precious and non-renewable resource, using a concept that encompassed rational use, moving away from the concept of cost containment, which had prevailed until then.
Choosing the optimal antibiotic dose includes the pathogen’s minimum inhibitory concentration, site, and severity of infection; also, the patient volume of distribution, renal clearance, weight, and organ support should be considered. Application of pharmacokinetic/pharmacodynamic (PK/PD) concepts in antimicrobial prescription are a stone in AMS programs.
This Research Topic proposes a set of articles to highlight the importance of PK/PD:
- The importance of PK/PD on antimicrobial stewardship
- How TDM can improve antimicrobial stewardship?
- Designing the optimal dose of aminoglycosides in gram-negative infections.
- Vancomycin TDM for every patient? Breaking rules.
- Beta-lactam TDM, the next barrier to cross.
- Achieving optimal antimicrobial dose in ICU care.
Keywords: Pharmacokinetic, pharmacodynamic, antimicrobial stewardship, therapeutic drug monitoring, optimal antimicrobial dose, rational antimicrobial prescription
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