Programmed Cell Death 2.0: The Quality of Cell Death, Volume III

As a fundamental biological process, actively programmed cell death has important implications for physiological processes. Studies over the past decades elucidated several key cell death signaling pathways and their possible consequences. From those studies, now we know the impacts of the cell death could go far beyond cellular demise. For example, cell death can modulate their microenvironments, such as inducing or inhibiting certain innate or adaptive immune system. It may also stimulate the neighbor cell proliferations, known as “compensatory proliferation”. Thus, we believe the next generation cell death studies are not only just to continue deciphering the cell death machineries. They will also expand to decode the physiological response to each specific mode of cell death mechanism. That is ”the quality of cell death”.

In this Research Topic, we would like to assemble cutting-edge views on the consequences of programmed cell death and the mechanisms that determine those effects. We aim to cover promising, recent, and novel research trends exploring the relationship of cell death mechanisms and microenvironments. Studies using multiple disciplines of approaches, such as molecular and cellular biology, genetics, biochemistry, immunology, bioinformatics, biostatics and clinical analysis are highly encouraged. Studies involving physiologically relevant cellular or animal models are especially welcome.

Original research, reviews, mini-reviews, study protocols, and hypotheses papers are welcome. Sub-topics may include, but not limited to:
- Novel cell death mode discoveries.
- The roles of cell death in physiological process.
- Mechanisms that determine the physiological impacts of dead cells.
- The non-killing functions of the cell death machineries.
- Therapeutic implications of cell death regulation.