About this Research Topic
Neurons have been a focal target for investigation of the pathogenesis and therapeutic potential in neurological disorders such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis, and ischemic brain injury. Although some of the mechanisms, including oxidative stress and inflammation, followed by apoptosis, are thought to be involved in the pathogenesis of these diseases, pathological mechanisms remains unknown. There is a consensus on the involvement of non-neuronal cells in the pathological progression of these diseases. Recently, glial cells are gaining attention as key players of non-cell autonomous neurodegeneration in neurological disorders, especially glial crosstalk and its action on neurons. It is demonstrated that microglia convert astrocytes to neurotoxic reactive A1 astrocytes, and it is also reported that astrocytes activate microglia to produce neuroinflammation. Astrocyte-microglia crosstalk contributes to the degradation of protein aggregates and recent studies indicated that microglia-oligodendrocyte or astrocyte-oligodendrocyte interactions promoted neuronal dysfunction and neurodegeneration. Thus, glial communication could be a main target to understand pathological mechanisms and develop neuroprotective therapeutic approaches for these disorders.
The main goal of this Special Issue is to present glial communication, astrocyte-microglia, microglia-oligodendrocyte, and oligodendrocyte-astrocyte interactions, in the neuropathological condition, and its impact on neuronal dysfunction. This Special Issue can produce discussion about therapeutic strategies with glial crosstalk as a target for the development of disease-modifying therapies for neurological disorders in the future.
We welcome Original Research that includes, but is not limited to, the following themes:
• Crosstalk between astrocytes and microglia, microglia and oligodendrocytes, or oligodendrocytes and astrocytes in neurodegeneration or neuronal dysfunction using cellular or animal models of neurological disorders
• Glial communications which contribute to degradation or cell-to-cell propagation of protein aggregates
• Glial crosstalk as a target for neuroprotection in neurological disorders
We also welcome Review, Mini Review and Brief Research Report articles on above themes in glial interaction in neurological disorders.
The main goal of this Special Issue is to present glial communication, astrocyte-microglia, microglia-oligodendrocyte, and oligodendrocyte-astrocyte interactions, in the neuropathological condition, and its impact on neuronal dysfunction. This Special Issue can produce discussion about therapeutic strategies with glial crosstalk as a target for the development of disease-modifying therapies for neurological disorders in the future.
We welcome Original Research that includes, but is not limited to, the following themes:
• Crosstalk between astrocytes and microglia, microglia and oligodendrocytes, or oligodendrocytes and astrocytes in neurodegeneration or neuronal dysfunction using cellular or animal models of neurological disorders
• Glial communications which contribute to degradation or cell-to-cell propagation of protein aggregates
• Glial crosstalk as a target for neuroprotection in neurological disorders
We also welcome Review, Mini Review and Brief Research Report articles on above themes in glial interaction in neurological disorders.
Keywords: glial cells, oligodendrocytes, astrocytes, microglia
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
