About this Research Topic

Background

Bone is an adaptable tissue, constantly changing to meet the body's needs. In order to keep bone mass steady and adapt to functional load, the body undergoes a process called remodeling. Bone homeostasis refers to the biological equilibrium maintained by the continuous process of bone remodeling, which is managed by bone creation and bone resorption simultaneously. By keeping internal conditions stable, the body can keep performing normally. Contrarily, bone disease occurs when homeostasis is disrupted, or the equilibrium is no longer maintained. Therefore, bone homeostasis relies heavily on appropriately calibrated bone remodeling.

Abnormalities in bone remodeling are linked to virtually every skeletal disorder. Several disorders, such as osteoporosis, osteoarthritis, rheumatoid arthritis, and age-related bone loss, increase the risk of bone break and joint damage because of the unbalanced influence of bone remodeling. Osteoclasts, osteoblasts, and osteocytes all play important regulatory roles in maintaining a dynamic balance known as bone homeostasis. Primary bone cells, or osteoblasts, are derived from mesenchymal stem cells (MSCs). As they settle into the mineralized matrix, they undergo a final stage of differentiation into osteocytes. Cells of the osteoblastic lineage aid in the development and differentiation of osteoclasts, which themselves develop from hematopoietic stem cells. As long as the functions of these cells are appropriately balanced, homeostasis in the skeletal system is preserved, and net bone mass is preserved. In order to effectively prevent and cure bone diseases, knowledge of the molecular connections and regulatory processes that keep bones in a healthy state is crucial.

The goal of this Research Topic is to collect Original Research and Review articles that will aid in the discovery of complex regulatory mechanisms underlying bone homeostasis and the development of novel treatment approaches and translational medicine. Potential subtopics include, but are not limited to

• Molecular mechanisms and signaling of bone development and metabolism;
• Key molecules and signal networks for maintaining bone remodeling and homeostasis;
• Novel cell-cell interactions regulating bone homeostasis;
• The pathological roles of bone homeostasis in bone diseases, including osteoporosis, osteoarthritis, and rheumatoid arthritis.

Keywords: Bone homeostasis, Bone remodeling, Bone cells, Bone disease

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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