About this Research Topic
The primary goal of this Research Topic is to promote recent development and understanding of the cell populations and cytokines that correlate with detrimental pathology or beneficial tissue healing processes leading to disease or health. Though vaccines, therapeutic antibodies, and drugs are used extensively to protect humans and animals against these infections with varying success, a precise map of immune correlates of protection is still poorly defined. Multiple studies have reported that neutralization, the Fc-effector functions of antibodies, mucosal antibodies, and immune cells such as memory B cells, CD4+ and CD8+ T cells are involved either alone or in combination in contributing to protection against various pathogens.
Hence, to achieve a broader insight, it is important to understand the signal mechanisms and cross-talks of all probable correlates of protection. Such an approach is imperative to develop effective vaccines and therapeutic antibodies. The aim of this Research Topic is to explore all the cell-specific evidence at genomic, transcriptomic, and proteomic levels that create dysregulated inflammation. Besides understanding the cytokine/cell populations, genetics, age, health, metabolism, and vaccination methods would all help in designing next-generation vaccines.
This Research Topic will address key questions to improve our understanding of the immune dynamics that correlate with protection. All types of papers including original research articles, reviews, mini-reviews, perspectives, and clinical studies will be accepted. The potential topics include, but are not limited to:
• Immune correlates of protection during superinfection and interplay among immune signaling molecules.
• Bacterial or fungal secondary infection during influenza infections
• Impact of the microbiome/colonization on co-infection
• Protective efficacy of vaccine-induced immune responses against co-infection
Keywords: influenza, streptococcus pneumoniae, co-infection, superinfection, immune cells, cytokines and chemokines, neutralizing antibodies, Vaccine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.