About this Research Topic
However, many infectious diseases can modulate our cellular processes and the pathways involved in apoptosis. Like Human Immunodeficiency Virus (HIV) which through proteins like gp120 can enhance the levels of CD4 T-lymphocyte apoptosis, within both affected cells and neighboring cells. Or the Herpes Simplex Virus (HSV), which through modulating both caspase activation as well as RIPK3 activation controls both the apoptotic and necroptotic pathways respectively allowing lifelong viral propagation. Or more recently with the COVID-19 pandemic and its link between cell death is still limited, studies are indicating a link to autophagy as a vital part of the disease pathology.
Understanding pathogens regarding their effect on apoptotic and non-apoptotic cellular processes is vital to develop effective and comprehensive therapeutic strategies that are either life threatening or permanent once infected.
For this Research Topic we welcome submissions looking at, but not limited to:
- Inflammasome-dependent host cell death pathways during infection
- Immunogenic cell death
- Infection-associated apoptosis modulation for therapeutic approaches (e.g. antiretroviral therapy)
- Disease pathology of infectious diseases, such as HIV, Herpes, COVID-19, Zika and Malaria
Keywords: Cell Death, Apoptosis, HIV, HSV-1, Autophagy, Immunogenic Cell Death, Malaria, Zika, COVID-19, Non-apoptotic Cell Death
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.