About this Research Topic
Sunlight reaching the Earth's surface includes ultraviolet (UV), visible, and infrared wavelengths. UV radiation is a major environmental hazard to the skin, disturbing skin homeostasis and contributing to several skin diseases, including inflammation, pigmentation disorders, cancer, and photoaging. In fact, UVA is the most abundant solar radiation (approximately 95%). Although it is less erythematogenic and less carcinogenic than UVB, when the skin is chronically exposed to UVA, free radicals are produced in the form of singlet oxygen together with hydroxyl radicals. These free radicals damage cellular structures by interacting with lipids, proteins, and DNA, and induce oxidative stress, mitochondrial damage, inflammation, and apoptosis, leading to symptoms such as premature skin aging, skin immunosuppression, and promoting UVB-induced skin cancer. In this regard, UVA radiation also has been shown to be involved in the phenomenon of melanin chemiexcitation generating DNA photoproducts in the dark. On the other hand, certain pollutants can act as photosensitizers when absorbing sunlight in the UVA range, demonstrating a synergy between environmental pollutants and UVA.
In the last years, sunscreens and oral photoprotection have been upgraded to protect against the detrimental effects elicited by UVA radiation. However, there is a need to further deepen and strengthen the knowledge about damaging effects on the skin, as well as evaluate new substances and reinforce the signaling pathways of existing compounds, mainly antioxidants and specific UVA-filters, proposed as photoaging and cancer, prevention agents.
Thus, this Research Topic aims to study the inflammatory and oxidant network induced by UVA exposure to provide new insights into skin damage prevention. We call for articles on specific photoprotection as well, especially from natural products. Both original research articles and review articles are welcome. Preferred subtopics include but are not limited to:
- Novel studies on the mechanism of UVA radiation
- Reappraisal of UVA phototherapy
- Novel targeted compounds against UVA radiation
- Novel natural products against UVA skin damage
- Research on natural UVA filters from plants
- New insights about the role of UVA in skin cancer
- Role of UVA radiation in skin pigmentation
- Effect of UVA radiation on pollutants
In the last years, sunscreens and oral photoprotection have been upgraded to protect against the detrimental effects elicited by UVA radiation. However, there is a need to further deepen and strengthen the knowledge about damaging effects on the skin, as well as evaluate new substances and reinforce the signaling pathways of existing compounds, mainly antioxidants and specific UVA-filters, proposed as photoaging and cancer, prevention agents.
Thus, this Research Topic aims to study the inflammatory and oxidant network induced by UVA exposure to provide new insights into skin damage prevention. We call for articles on specific photoprotection as well, especially from natural products. Both original research articles and review articles are welcome. Preferred subtopics include but are not limited to:
- Novel studies on the mechanism of UVA radiation
- Reappraisal of UVA phototherapy
- Novel targeted compounds against UVA radiation
- Novel natural products against UVA skin damage
- Research on natural UVA filters from plants
- New insights about the role of UVA in skin cancer
- Role of UVA radiation in skin pigmentation
- Effect of UVA radiation on pollutants
Keywords: ultraviolet A radiation, oxidative stress, photoaging, mitochondrial damage, cell senescence, skin cancer, skin pigmentation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
