Metabolism is the fundamental process to generate a store of energy by catabolism, and to generate macromolecules for cell maintenance and growth through anabolic pathways. Immune cells experience dynamic and adaptive metabolic changes throughout their life cycles. Stimulated immune cells mounting an ...
Metabolism is the fundamental process to generate a store of energy by catabolism, and to generate macromolecules for cell maintenance and growth through anabolic pathways. Immune cells experience dynamic and adaptive metabolic changes throughout their life cycles. Stimulated immune cells mounting an inflammatory response is an energy-intensive process under inflammatory conditions. For instance, glucose metabolism and aerobic glycolysis drive classical macrophage activation. T cell activation is accompanied by enhanced glucose metabolism and oxidative phosphorylation. Emerging evidence has demonstrated that metabolic change was not only response to inflammatory microenvironment; they also guide immune cell differentiation and function via several mechanisms. The metabolic state of an immune cell can directly influence its ability to function and differentiate, ultimately affecting immunity and the inflammatory process. More importantly, advanced existing immunosuppressant drugs also interfered with cell metabolism have been studied with those findings in immunometabolism. Thus, increasing our knowledge of the mechanism of metabolic reprogramming during immunity and inflammation will be invaluable for developing new therapeutic strategies.
This Research Topic aims to understand the role of metabolism in immunity and inflammation. Particularly, advanced findings of changes in metabolism that occur in immunity and inflammation may provide new evidence to understand disease pathogenesis and point the way to hold substantial therapeutic promise.
In this Research Topic, we focus on molecular links between metabolism and mechanisms of immunity and inflammation. We welcome the submission of original research and review manuscripts that may cover any of the following aspects:
Insight into the changes in metabolism and metabolite that occur in immunity and inflammation.
Regulation of key metabolic enzymes and its impact as well as mechanism on inflammation progress.
Contributions of differential metabolic regulation in immune cells to disease and therapeutic implications.
Immune microenvironments correlate with disease progression.
Furthermore, we also hope to shed light on future avenues of research in this domain that could impact the development of new therapeutic modalities.
Keywords:
metabolism, immunity, inflammation
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.