New Basic and Translational Perspectives on Skin Repair

Skin, the largest organ of the human body, makes up the main barrier to prevent the invasion of pathogenic organisms and the loss of water. Any injuries to the skin caused by trauma, diseases, or aging will lead to skin dysfunctions, resulting in a series of physical and mental disorders. Wound healing is a complex and fragile process, accompanied by hemostasis, inflammation, proliferation, and remodeling. Any abnormality in each process may lead to delayed wound healing and/or conspicuous scars. In addition, direct contact with the outside environment and stimulation by various external factors, such as ultraviolet radiation, microorganisms, etc., will cause a series of inflammatory reactions, leading to skin cell aging, affecting stem cell activity and wound healing. Therefore, it is necessary to have a deep understanding of the mechanisms of skin injuries and to explore effective prevention and therapeutic strategies to facilitate the process of skin repair.

This Research Topic aims to discuss the use of various biological and biophysical technologies in the process of skin injury and its repair, which is beneficial for us to have a more comprehensive and in-depth understanding of the physiological and pathophysiological mechanisms of skin injury and skin injury repair. On this basis, with the use of biological technology, biophysics, bioengineering, and other technologies (including basic and translational medical research), repair of skin injuries could be achieved. Therefore, we welcome submissions on the following topics:
• Mechanisms of inflammation in wound healing;
• Mechanisms of epithelial proliferation and remodeling during skin repair;
• Mechanism of scar formation during wound healing;
• Skin repair during skin aging;
• Biomaterials and tissue engineering materials for skin repair.