About this Research Topic
Communication among the different cells of the brain, including all neurons, glial cells, and their progenitors, is essential to maintain brain functions and environmental homeostasis. In this regard, both soluble biological molecules and extracellular vesicles (EVs) are essential players, able to modulate cellular crosstalk, in terms of miRNAs, lipids, and proteins. Furthermore, the disruption of physiological conditions might alter the release of soluble factors, as well as vesicles’ content, and consequently impair cellular communication. Worth of note, both soluble and vesicular release and the following interplay between neighboring cells can occur through a reciprocal interaction among all brain cells.
Given recent evidence of the role of released factors and EVs in modulating communication among brain cells, the goal of the proposed Research Topic is to fill the gap in the understanding of the role of soluble factors, as well as the properties and the content of EVs released by glia and neurons, either in physiological conditions or in response to neurodegenerative/neuropsychiatric diseases, in vitro and in vivo and investigate their impact on target cells.
In this regard, by a multidisciplinary approach, we would like contributors to address their interest in the identification of soluble factors, as well as the structural and compositional characterization of EVs and their functional role in the modulation of neurophysiological processes. Including brain inflammation and neuronal dysfunction in pathological conditions. Also, the characterization of contents of EVs can pave the way for the identification of potential new biomarkers in brain-derived extracellular vesicles.
The Research Topic welcomes both Original Research Articles and Review Articles that dissect the physical and morphological properties, as well as the composition of EVs, able to modulate the communication between brain cells, both in vitro and in vivo models of brain physiopathology and that may have a potential clinical role.
Given recent evidence of the role of released factors and EVs in modulating communication among brain cells, the goal of the proposed Research Topic is to fill the gap in the understanding of the role of soluble factors, as well as the properties and the content of EVs released by glia and neurons, either in physiological conditions or in response to neurodegenerative/neuropsychiatric diseases, in vitro and in vivo and investigate their impact on target cells.
In this regard, by a multidisciplinary approach, we would like contributors to address their interest in the identification of soluble factors, as well as the structural and compositional characterization of EVs and their functional role in the modulation of neurophysiological processes. Including brain inflammation and neuronal dysfunction in pathological conditions. Also, the characterization of contents of EVs can pave the way for the identification of potential new biomarkers in brain-derived extracellular vesicles.
The Research Topic welcomes both Original Research Articles and Review Articles that dissect the physical and morphological properties, as well as the composition of EVs, able to modulate the communication between brain cells, both in vitro and in vivo models of brain physiopathology and that may have a potential clinical role.
Keywords: intercellular communication, neurons, glia, extracellular vesicles (EVs), miRNAs, cytokines, lipids, proteins, signaling molecules.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
