About this Research Topic
Salmonellae, typically known for causing intestinal infections, also contribute significantly to an underestimated global burden of invasive diseases. The clinical manifestations of Salmonellosis vary across geographical regions and specific strains. In South and South-East Asia, enteric fever is primarily linked to serovars Typhi and Paratyphi A, while sub-Saharan Africa faces a similar burden primarily from invasive nontyphoidal Salmonellae, like Typhimurium and Enteritidis.
Although vaccines targeting specific Salmonella serovars exist, their effectiveness is limited, particularly in young children who bear a significant part of the Salmonella-related disease burden. Moreover, no approved vaccines currently target invasive nontyphoidal Salmonella.
Salmonellae, functioning as facultative intracellular pathogens, employ a dual survival strategy, existing both extracellularly and within host cells. This dual nature poses a unique challenge for vaccine development, necessitating a comprehensive approach. Effective vaccines against Salmonella-related diseases must stimulate both humoral immunity to combat extracellular bacteria and cellular immunity to eliminate intracellular pathogens. This multifaceted strategy is vital for effectively addressing Salmonella infections.
Since the complex immunity of Salmonella, the lack of a clear correlate of protection, and the wide emergence of multidrug-resistant strains, it is of critical importance to reinforce effective interventions and contribute to the study of protective vaccination strategies able to induce a robust and effective immune response. The delay in the research in the field might be attributed to the lack of a clear commercial incentive for developing vaccines against Salmonella. Currently, new effective vaccines, alternative approaches, and innovative strategies of vaccination against Salmonella infection are needed, especially suitable for low-income countries. On the other hand, it is essential to characterize the magnitude, quality, and persistence of immune response generated by new vaccinations to evaluate promising candidates to introduce in clinical studies.
This Research Topic accepts Original Research, Systematic Review, Methods, Review and Mini-Review, Clinical Trial, Case Report, General Commentary. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Innovative vaccination approaches against Salmonella infection
• Profiling the humoral and cellular immune response elicited by Salmonella vaccines
• Descriptive comparisons of vaccine efficacy
• Animal infection models to test new candidate vaccines
Although vaccines targeting specific Salmonella serovars exist, their effectiveness is limited, particularly in young children who bear a significant part of the Salmonella-related disease burden. Moreover, no approved vaccines currently target invasive nontyphoidal Salmonella.
Salmonellae, functioning as facultative intracellular pathogens, employ a dual survival strategy, existing both extracellularly and within host cells. This dual nature poses a unique challenge for vaccine development, necessitating a comprehensive approach. Effective vaccines against Salmonella-related diseases must stimulate both humoral immunity to combat extracellular bacteria and cellular immunity to eliminate intracellular pathogens. This multifaceted strategy is vital for effectively addressing Salmonella infections.
Since the complex immunity of Salmonella, the lack of a clear correlate of protection, and the wide emergence of multidrug-resistant strains, it is of critical importance to reinforce effective interventions and contribute to the study of protective vaccination strategies able to induce a robust and effective immune response. The delay in the research in the field might be attributed to the lack of a clear commercial incentive for developing vaccines against Salmonella. Currently, new effective vaccines, alternative approaches, and innovative strategies of vaccination against Salmonella infection are needed, especially suitable for low-income countries. On the other hand, it is essential to characterize the magnitude, quality, and persistence of immune response generated by new vaccinations to evaluate promising candidates to introduce in clinical studies.
This Research Topic accepts Original Research, Systematic Review, Methods, Review and Mini-Review, Clinical Trial, Case Report, General Commentary. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Innovative vaccination approaches against Salmonella infection
• Profiling the humoral and cellular immune response elicited by Salmonella vaccines
• Descriptive comparisons of vaccine efficacy
• Animal infection models to test new candidate vaccines
Keywords: Innovative approaches, Vaccine formulations, Vaccination, Immune response, Salmonella
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
