About this Research Topic
Early embryo development is a critical stage encompassing a series of crucial events, such as the transition from oocyte to an embryo, first cell divisions, the establishment of cellular contacts, differentiation and growth of three germ layers, etc. In this stage, genetic risk factors such as gene mutations, chromosomal abnormalities, and epigenetic events will lead to abnormal embryo development, causing a low pregnancy rate. Therefore, screening early-stage embryos to avoid implanting those with genetic defects is critical to achieving a successful in vitro fertilisation (IVF) pregnancy and giving birth to a healthy baby. Unfortunately, we are far from knowing how to avoid abnormal embryos caused by genetic risk factors. In recent years, although some new technologies, such as ART and NGS have been used to screen embryos with genetic defects, these also have certain limitations. Therefore, we are here to discuss the impact of genetic risk factors on the development of embryos, and to seek new technologies to remove the embryos with genetic defects, expecting to find better ways to increase the IVF pregnancy rate and give birth to a healthy baby.
This Research Topic aims to explore genetic factors that affect early embryo growth, development, and survival. Furthermore, by discussing new technology for screening early-stage embryos to avoid implanting those with genetic defects, it will not only give embryologists new insights into the critical stages of embryo development but also new technology for screening embryos, increasing IVF pregnancy rate and the reduction of the risk of birth defects.
In this Research Topic, we welcome the submission of Original Research articles, Reviews, Clinical Trials, and Prospective or Retrospective studies. Perspective and opinion articles focusing on the following areas:
• Current progress in genetic or epigenetic mechanisms of early human embryonic development.
• Abnormal genetic or epigenetic mechanisms associated with embryo implantation and abnormal organ development during early embryonic development and embryo selection.
• Novel technology, improvement and innovation of embryo assessment methods for embryo selection.
Topic Editor Gábor Vajta is a shareholder and CSO of VitaVitro Co., Ltd. Other Topic Editors declare no conflicts of interest with the Research Topic.
This Research Topic aims to explore genetic factors that affect early embryo growth, development, and survival. Furthermore, by discussing new technology for screening early-stage embryos to avoid implanting those with genetic defects, it will not only give embryologists new insights into the critical stages of embryo development but also new technology for screening embryos, increasing IVF pregnancy rate and the reduction of the risk of birth defects.
In this Research Topic, we welcome the submission of Original Research articles, Reviews, Clinical Trials, and Prospective or Retrospective studies. Perspective and opinion articles focusing on the following areas:
• Current progress in genetic or epigenetic mechanisms of early human embryonic development.
• Abnormal genetic or epigenetic mechanisms associated with embryo implantation and abnormal organ development during early embryonic development and embryo selection.
• Novel technology, improvement and innovation of embryo assessment methods for embryo selection.
Topic Editor Gábor Vajta is a shareholder and CSO of VitaVitro Co., Ltd. Other Topic Editors declare no conflicts of interest with the Research Topic.
Keywords: embryo development, embryo selection, genetic, epigenetic, genetic disorders
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
