About this Research Topic

Background

Circadian rhythms are the daily fluctuations in physiological processes that govern cell cycles and timing of behaviors. Cancer hallmarks are the cellular properties that drive the perennial growth, survival and spread of cancerous cells. The disruption of circadian rhythms can contribute to the development of some cancers by affecting the expression of genes that regulate cell growth and division, as well as their interaction with the host microenvironment and anti-cancer treatment. Some cancer cells have been found to have altered circadian rhythms compared to normal cells, which may contribute to their uncontrolled growth. Patients exhibiting disrupted circadian rhythms tend to suffer accelerated tumor growth and metastasis, tumors that are more resistant to treatment, and poorer health-related quality of life and overall survival. Circadian rhythms also temporally regulate cellular immunity, which has important implications for the burgeoning field of immune-based therapeutics. Further research is needed to better understand the relationship between circadian rhythms and cancer hallmarks, and how this knowledge can be used to improve immunotherapy outcomes, cancer patients’ well-being and survival.

This timely research topic is focused within a field that produced two Nobel prize awards in Physiology or Medicine, in 2017 for circadian rhythm research, and in 2018 for the discovery of cancer immunotherapy. The aim of this special issue is to highlight clinical, translational and epidemiological science - that includes objective assessments of both circadian disruption and cancer hallmarks - in order to help elucidate the impact of circadian rhythms on processes associated with cancer and its treatments, immunotherapy in particular.

We welcome submission of Reviews, Original Research and Methodological Articles, with a special interest in the following research topics:
- Science focused on the newly proposed hallmark parameters of “unlocking phenotypic plasticity,” “nonmutational epigenetic reprogramming,” “polymorphic microbiomes,” and “senescent cells”
- Experimental, translational or clinical evidence on the impact of circadian rhythms on the efficacy and safety of immune-based anticancer therapeutics (immune checkpoint inhibitors, chimeric antigen receptor T-cell therapy, cytokines)
- Advancements in clinical measurements of circadian rhythms (eg, wearable biosensors and e-health technology) to derive non-invasive measures, in addition to establishing clinical cutoff scores, with the aim of more easily integrating circadian measurements into clinical practice, especially in patients on immunotherapy
- Clinical strategies that advance precision in targeting chrono- and behaviorally-modulated treatments (eg, pharmacologic timing, exercise, bright light exposure, chrono-nutrition) in cancer survivors
- Studies that aim to evaluate the impact of circadian rhythms on response to immune-based cancer treatment in humans.
- Data on the circadian rhythm changes in cancer cells and normal cells under different treatments, particularly immunotherapy.
- Evidence on the circadian modulation of the interaction between cancer cells and tumor microenvironment, in particular immune cells
- Data on circadian rhythms and cancer stem cells
- Clinical data on the impact of circadian rhythm disruption on cancer recurrence and progression after treatment, and/or side-effects of immunotherapy and other cancer treatments.
- Gaining a better understanding of how sleep and circadian rhythm disruption each differentially influence host-tumor defenses to delineate which of these two processes may be the stronger driver of cancer cell growth and progression, as well as cancer treatment response, particularly to immunotherapy.

Keywords: circadian, cancer, immuno-oncology, clock gene, cancer hallmarks, chronotherapy, cancer therapeutics

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

• What is a Research Topic?

  Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

  Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

• Why does Frontiers publish Research Topics? 

  The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

  Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

• Why are Research Topics important for journals?

  As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

  A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

• How do we ensure the quality of articles within Research Topics?

  Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

  In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

• What are the benefits of publishing my article in a Research Topic?

  Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

  As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

  Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

   
• What types of articles can be published in a Research Topic?

  Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

  Check available article types here 

• Can I suggest a new Research Topic? 

  Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

  Suggest your topic here 

• Who leads a Research Topic? 

  A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

  The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

• What is the role of a topic editor?

  As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

   

  You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

• What support will I receive when editing a new Research Topic? 

  As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

• As a junior researcher, can I be involved in editing a Research Topic? 

  If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

• Can I get a certificate for editing a Research Topic?

  Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

• Who will I collaborate with?

  Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

• How long does it take to publish a Research Topic?

  As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

  Find out more about our Research Topics

• What fee support is available to authors publishing in a Research Topic?

  Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

  Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

• Will there be a printed version of my Research Topic?

  In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.