About this Research Topic
Nutrition has a huge impact on human bone development, with nutritional status influencing key periods of bone growth, development and health. Poor nutrition can compromise bone mass, leading to premature bone loss and increased risk of injury. The bone is a living tissue that is constantly growing, being broken down and remodeled into new bone. At a younger age, the process is the most efficient, however as we age the process slows down. So, at around 30 years of age the body stops increasing in bone mass. By the age of 40 - 50 years, the rate of bone resorption may exceed the rate of bone formation. Women post menopause are also particularly at risk of osteoporosis due to loss of the hormone oestrogen. Aside from gender and age, other risk factors include heredity, sedentary lifestyle, smoking, and excessive alcohol consumption.
Probiotic intake has been shown to improve the intestinal gut lining, thereby improving calcium balance, preventing secondary hyperparathyroidism, and reducing the effect of age-related increase of bone resorption and bone loss. These probiotics, when taken in adequate amounts, release metabolites (e.g., short chain fatty acids) from nutrients such as vitamins, amino acids, or dietary fiber. These metabolites may induce changes to the microbial composition of the gut, provide energy sources for the epithelial cells of the human colon, immune cells and induce proliferation of beneficial microbes in the gastrointestinal tract. The colonization of the gut by specific beneficial bacteria may therefore ameliorate pro-inflammatory immune cell recruitment into the intestinal and systemic lymphoid tissues. These immunomodulation effects on bone cells and bone regeneration can be referred to as the gut-bone axis i.e., the communication between the gut microbiota and the skeletal system.
New breakthroughs in understanding the impact of nutrition on bone health, including the role of the microbiome on the gut-bone axis, are furthering our understanding of the potential to reinforce nutrition, and in turn bone strength.
The aim of the current Research Topic is to cover promising, recent, and novel research trends in the field of nutrition and the gut-bone axis. Original research articles, Protocols, Systematic Reviews and Meta-analyses are welcomed. Areas to be covered in this Research Topic may include, but are not limited to:
• Nutrition and bone health
• The impact of nutritional challenges on bone development
• Gut microbiome and bone strength
• Probiotic intake and bone cells
• Probiotic intake and gut microbiota
• Application of Probiotic supplements and the gut-bone axis
We accept different article types including Mini-Reviews, Brief Research Reports and Perspectives. A full list of accepted article types, including descriptions, can be found at this link. Comprehensive studies are highly encouraged.
Probiotic intake has been shown to improve the intestinal gut lining, thereby improving calcium balance, preventing secondary hyperparathyroidism, and reducing the effect of age-related increase of bone resorption and bone loss. These probiotics, when taken in adequate amounts, release metabolites (e.g., short chain fatty acids) from nutrients such as vitamins, amino acids, or dietary fiber. These metabolites may induce changes to the microbial composition of the gut, provide energy sources for the epithelial cells of the human colon, immune cells and induce proliferation of beneficial microbes in the gastrointestinal tract. The colonization of the gut by specific beneficial bacteria may therefore ameliorate pro-inflammatory immune cell recruitment into the intestinal and systemic lymphoid tissues. These immunomodulation effects on bone cells and bone regeneration can be referred to as the gut-bone axis i.e., the communication between the gut microbiota and the skeletal system.
New breakthroughs in understanding the impact of nutrition on bone health, including the role of the microbiome on the gut-bone axis, are furthering our understanding of the potential to reinforce nutrition, and in turn bone strength.
The aim of the current Research Topic is to cover promising, recent, and novel research trends in the field of nutrition and the gut-bone axis. Original research articles, Protocols, Systematic Reviews and Meta-analyses are welcomed. Areas to be covered in this Research Topic may include, but are not limited to:
• Nutrition and bone health
• The impact of nutritional challenges on bone development
• Gut microbiome and bone strength
• Probiotic intake and bone cells
• Probiotic intake and gut microbiota
• Application of Probiotic supplements and the gut-bone axis
We accept different article types including Mini-Reviews, Brief Research Reports and Perspectives. A full list of accepted article types, including descriptions, can be found at this link. Comprehensive studies are highly encouraged.
Keywords: Probiotics, inflammation, cytokines, gut health, gut microbiota, bone health, osteoporosis, bone cells, nutrition
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
