About this Research Topic
Organelles and endolysosomes form an intracellular network that constantly and dynamically interconverts to generate vesicles with a unique identity that modulates cargo sorting, targeted protein degradation, and membrane recycling based on changing stimuli. When healthy, this network plays a central role in regulating the steady-state and remodeling of the membrane protein and lipid composition required to update cell signaling, nutrient intake, cell polarity, proliferation, and migration, ultimately impacting brain development and homeostasis. Golgi is at the center of this network, and its morphology, position, and function can vary considerably during various physiological cell processes and, as recently emerging, precise Golgi fragmentation patterns can be distinctive features of rare neurodevelopmental conditions and neurodegeneration. On the other hand, experiments using cytoskeletal activity modifiers have been fundamental to beginning our understanding of the crosstalk between microtubules, actin, intermediate filaments, and biosynthetic trafficking and their role in cell physiology and homeostasis. Clearly, not only is the cytoskeleton essential for organelles and vesicles positioning inside the cell and thereby their function but disrupted interplay between Golgi proteins and tubulin chaperons can alter both microtubule dynamics and Golgi integrity, as an early underlying mark of motoneuron degeneration.
Despite fundamental scientific advances, the relevance of the possible differential mechanisms involving variable Golgi changes and microtubule interactions in the etiology of heterogeneous forms of neurodevelopmental conditions and neurodegeneration remains largely unexplored. This knowledge could support differential diagnosis, early marker detection, and tailored therapies. Novel technologies and approaches, which promise to surpass the long-standing technical difficulties in discriminating fine aspects of Golgi morphotypes, microtubule dynamics, and trafficking in living organisms, allowing fine control of these processes, can now enhance our interrogation abilities to distinguish specific pathomechanisms.
Therefore, this Research Topic aims to collect the latest experimental results and critical scientific and methodological assessment of the field and literature, which would offer a comprehensive and up-to-date knowledge of the differential mechanisms involving Golgi, endolysosomal, and cytoskeletal network crosstalk for the etiopathogenesis of brain diseases. The Research Topic also intends to report on the latest technical advances - including pioneer concepts- in functional imaging and quantitative analyses of organelles dynamics, with reporters and actuators tools quickly becoming available, which could resolve unknown physiopathological mechanisms potentially in whole organisms.
We welcome Original Research articles and short communications providing novel information related to the following sub-topics (including but not limited to):
Identification and characterization of novel cellular pathways and components involving Golgi (and/or Golgi stress response) and the endolysosomal network which contribute to central and peripheral nervous system development, homeostasis, and disease.
Functional impact of mutations affecting small GTPases and their effectors and altering different steps of the biosynthetic trafficking and cytoskeleton dynamics in neurodevelopmental diseases.
Methodological work describing novel approaches to actively perturb and interrogate organelles and vesicles morphological and functional changes, cytoskeletal dynamics, and resulting intracellular signaling in intact cell populations with a focus on the potential in vivo applications.
We also encourage authors to submit Review Articles highlighting the most recent advancements and debates in the above-discussed areas.
More information on article types accepted by the journal can be found here.
Despite fundamental scientific advances, the relevance of the possible differential mechanisms involving variable Golgi changes and microtubule interactions in the etiology of heterogeneous forms of neurodevelopmental conditions and neurodegeneration remains largely unexplored. This knowledge could support differential diagnosis, early marker detection, and tailored therapies. Novel technologies and approaches, which promise to surpass the long-standing technical difficulties in discriminating fine aspects of Golgi morphotypes, microtubule dynamics, and trafficking in living organisms, allowing fine control of these processes, can now enhance our interrogation abilities to distinguish specific pathomechanisms.
Therefore, this Research Topic aims to collect the latest experimental results and critical scientific and methodological assessment of the field and literature, which would offer a comprehensive and up-to-date knowledge of the differential mechanisms involving Golgi, endolysosomal, and cytoskeletal network crosstalk for the etiopathogenesis of brain diseases. The Research Topic also intends to report on the latest technical advances - including pioneer concepts- in functional imaging and quantitative analyses of organelles dynamics, with reporters and actuators tools quickly becoming available, which could resolve unknown physiopathological mechanisms potentially in whole organisms.
We welcome Original Research articles and short communications providing novel information related to the following sub-topics (including but not limited to):
Identification and characterization of novel cellular pathways and components involving Golgi (and/or Golgi stress response) and the endolysosomal network which contribute to central and peripheral nervous system development, homeostasis, and disease.
Functional impact of mutations affecting small GTPases and their effectors and altering different steps of the biosynthetic trafficking and cytoskeleton dynamics in neurodevelopmental diseases.
Methodological work describing novel approaches to actively perturb and interrogate organelles and vesicles morphological and functional changes, cytoskeletal dynamics, and resulting intracellular signaling in intact cell populations with a focus on the potential in vivo applications.
We also encourage authors to submit Review Articles highlighting the most recent advancements and debates in the above-discussed areas.
More information on article types accepted by the journal can be found here.
Keywords: organelles, vesicles, cytoskeletal dynamics, neurodevelopment, neurodegenerative
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
