About this Research Topic
Intracerebral hemorrhage is a devastating condition with little treatment to date. Brain injury after intracerebral hemorrhage is caused by multiple mechanisms. Primary brain injury occurs as a result of direct physical disruption by hematoma or cerebral and systemic hemodynamic changes and is worsened by hematoma growth within the first few hours of onset. Secondary brain injury results from neuroinflammation, thrombin-mediated, complement-mediated, and erythrolysis-related processes, which start within hours and may persist for up to three weeks from onset. The processes of secondary brain injury result in the development and growth of perihematomal edema. Current treatments for intracerebral hemorrhage are limited due to a lack of knowledge about the possible targets to intervene in the brain injury elicited by intracerebral hemorrhage and the factors which may be considered for prognostic assessment and patient selection to treatment.
The goal of our Research Topic is to compile the latest research related to mechanisms and treatment of brain injury after intracerebral hemorrhage. We look forward to presenting recent advancements in clinical research on novel mechanisms of brain injury after intracerebral hemorrhage, methods of assessing brain injury, and treatment targeting specific mechanisms of brain injury after intracerebral hemorrhage.
We welcome the submission of any type of manuscript supported by the journal (including Original Research, Brief Research Report, Clinical Trial, Review, Systematic Review, etc.), on brain injury after intracerebral hemorrhage and pertaining to, but not limited to, the following themes:
- neuroimaging predictors of brain injury
- clinical significance of perihematomal edema
- management of perihematomal edema
- neuroinflammation, metabolomics, genetics, and neuroprotective agents in intracerebral hemorrhage
- prevention and treatment of hematoma expansion, avoiding therapeutic nihilism in intracerebral hemorrhage
- surgical management of intracerebral hemorrhage
- cerebral hemodynamics in intracerebral hemorrhage
- geographical difference of prognosis in intracerebral hemorrhage
We would prioritize clinical and translational studies involving humans but can consider pre-clinical studies.
The goal of our Research Topic is to compile the latest research related to mechanisms and treatment of brain injury after intracerebral hemorrhage. We look forward to presenting recent advancements in clinical research on novel mechanisms of brain injury after intracerebral hemorrhage, methods of assessing brain injury, and treatment targeting specific mechanisms of brain injury after intracerebral hemorrhage.
We welcome the submission of any type of manuscript supported by the journal (including Original Research, Brief Research Report, Clinical Trial, Review, Systematic Review, etc.), on brain injury after intracerebral hemorrhage and pertaining to, but not limited to, the following themes:
- neuroimaging predictors of brain injury
- clinical significance of perihematomal edema
- management of perihematomal edema
- neuroinflammation, metabolomics, genetics, and neuroprotective agents in intracerebral hemorrhage
- prevention and treatment of hematoma expansion, avoiding therapeutic nihilism in intracerebral hemorrhage
- surgical management of intracerebral hemorrhage
- cerebral hemodynamics in intracerebral hemorrhage
- geographical difference of prognosis in intracerebral hemorrhage
We would prioritize clinical and translational studies involving humans but can consider pre-clinical studies.
Keywords: intracerebral hemorrhage, brain injury, therapeutics, clinical trial, pathophysiology, hemodynamics, autoregulation, cerebral edema
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
