About this Research Topic
Long non-coding RNAs or lncRNAs are a group of untranslated RNAs of more than 200 nucleotides, comprising of intergenic ncRNAs, intronic ncRNAs, and sense and antisense lncRNAs. Although they are not translated into proteins, lncRNAs , through their complex secondary structure, interact with several important cellular macromolecules. The lncRNA interactome consists of proteins such as transcription factors acting as their guide, peptides, mRNAs, and miRNAs, and are also associated with the chromatin structure. Through these interactions, lncRNAs control gene expression at the transcriptional and translational level and have significant roles in several disease processes including pathways related to immune response and inflammation.
The lncRNA containing complexes play a critical role in modulating the tumor microenvironment and significantly impact immune and inflammatory processes that promote cancer progression. This presents diverse possibilities for lncRNA targeting therapeutics to alter the microenvironments characteristics and thereby inhibit tumorigenesis.
The main theme of this collection will focus on the studies exploring the paradigm of lncRNAs in complex physiological conditions related to cancer microenvironment and inflammation with their possible use as diagnostic markers and therapeutic targets for faster and more comprehensive management of inflammatory and cancer-associated damage. The collection also looks to demonstrate the interface between dysregulated immune system and inflammation-driven cancer progression and how lncRNAs are involved in the crosstalk.
• LncRNAs as the driver of inflammation of the tumor microenvironment.
• Regulation of the immune microenvironment and immune responses by lncRNAs
• Inflammation related LncRNAs as target for therapeutics.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
We accept different article types including Mini-Reviews, Brief Research Reports and Perspectives. A full list of accepted article types, including descriptions, can be found at this link.
The lncRNA containing complexes play a critical role in modulating the tumor microenvironment and significantly impact immune and inflammatory processes that promote cancer progression. This presents diverse possibilities for lncRNA targeting therapeutics to alter the microenvironments characteristics and thereby inhibit tumorigenesis.
The main theme of this collection will focus on the studies exploring the paradigm of lncRNAs in complex physiological conditions related to cancer microenvironment and inflammation with their possible use as diagnostic markers and therapeutic targets for faster and more comprehensive management of inflammatory and cancer-associated damage. The collection also looks to demonstrate the interface between dysregulated immune system and inflammation-driven cancer progression and how lncRNAs are involved in the crosstalk.
• LncRNAs as the driver of inflammation of the tumor microenvironment.
• Regulation of the immune microenvironment and immune responses by lncRNAs
• Inflammation related LncRNAs as target for therapeutics.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
We accept different article types including Mini-Reviews, Brief Research Reports and Perspectives. A full list of accepted article types, including descriptions, can be found at this link.
Keywords: lncrna
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
